13 Result(s)

Article

Topological structures and syntenic conservation in sea anemone genomes

There is currently little information about the evolution of gene clusters, genome architectures and karyotypes in early branching animals. Slowly evolving anthozoan cnidarians can be particularly informative ...

Bob Zimmermann, Juan D. Montenegro, Sofia M. C. Robb… in Nature Communications (2023)

Article

Transcriptome-wide map** of signaling pathways and early immune responses in lumpfish leukocytes upon in vitro bacterial exposure

We performed RNA sequencing, identified components of the immune system and mapped early immune responses of lumpfish (Cyclopterus lumpus) leukocytes following in vitro exposure to the pathogenic bacterium Vibrio...

Håvard Ø. Eggestøl, Harald S. Lunde, Anita Rønneseth, David Fredman… in Scientific Reports (2018)

Article

Meeting abstracts from the first European Emergency Medical Services congress (EMS2016)

Alexander White, Han **an Ng, Wai Yee Ng… in Scandinavian Journal of Trauma, Resuscitat… (2017)

Article

Adoption of conserved developmental genes in development and origin of the medusa body plan

The metagenesis of sessile polyps into pelagic medusae in cnidarians represents one of the most ancient complex life cycles in animals. Interestingly, scyphozoans and hydrozoans generate medusae by apparently ...

Johanna E. M. Kraus, David Fredman, Wei Wang, Konstantin Khalturin… in EvoDevo (2015)

Article

Characterisation and localisation of the opsin protein repertoire in the brain and retinas of a spider and an onychophoran

Opsins have been found in the majority of animals and their most apparent functions are related to vision and light-guided behaviour. As an increasing number of sequences have become available it has become cl...

Bo Joakim Eriksson, David Fredman, Gerhard Steiner, Axel Schmid in BMC Evolutionary Biology (2013)

Article

Making enhancers from spare parts of the genome

New studies show that novel long-range enhancers of developmental genes can emerge by exaptation of protein-coding sequences with no previous regulatory function.

David Fredman, **anjun Dong, Boris Lenhard in Genome Biology (2011)

Article

Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes

Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated ge...

**anjun Dong, David Fredman, Boris Lenhard in Genome Biology (2009)

Article

Transcriptional features of genomic regulatory blocks

Genomic regulatory blocks (GRBs) are chromosomal regions spanned by highly conserved non-coding elements (HCNEs), most of which serve as regulatory inputs of one target gene in the region. The target genes are...

Altuna Akalin, David Fredman, Erik Arner, **anjun Dong… in Genome Biology (2009)

Article

Ancora: a web resource for exploring highly conserved noncoding elements and their association with developmental regulatory genes

Metazoan genomes contain arrays of highly conserved noncoding elements (HCNEs) that span developmental regulatory genes and define regulatory domains. We describe Ancora http://ancora.genereg.n...

Pär G Engström, David Fredman, Boris Lenhard in Genome Biology (2008)

Article

Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes

A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovere...

Hiroshi Kikuta, David Fredman, Silke Rinkwitz, Boris Lenhard… in Genome Biology (2007)