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Article
A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population
Classic ways to determine MHC restriction involve inhibition with locus-specific antibodies and antigen presentation assays with panels of cell lines matched or mismatched at the various loci of interest. Howe...
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Article
Open AccessTNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media
Tumor necrosis factor (TNFA) is the canonical member of the TNF superfamily, which plays a major role in both inflammation and apoptosis. To evaluate the role of TNFs in otitis media (OM), the most common dise...
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Article
New targets for allergic rhinitis — a disease of civilization
Allergic rhinitis is a common manifestation of atopy whose prevalence world wide is increasing in association with a Western-type lifestyle.
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Chapter
Immunostimulatory DNA for Allergic Asthma
Asthma is a common disease afflicting 17 million Americans, or approx 7% of the United States population (1). Asthma has increased in prevalence and has been associated with increased morbidity and mortality over...
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Chapter
Modulation of asthmatic response by immunostimulatory DNA sequences
Asthma is a common disease in the USA affecting approximately 5% of the population. The expression of the allergic asthma phenotype is dependent upon both host genetic factors as well as environmental allergen...
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Article
Modulation of asthmatic response by immunostimulatory DNA sequences
A variety of DNA-based methods of modulating the immune and/or inflammatory response in animal models of asthma have shown significant promise. Antisense strategies seek to inhibit expression of specific host ...
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Protocol
Genetic Immunization for Allergy Immunotherapy
Allergic disorders are characterized by the prevalence of immunoglobulin (Ig) isotype E antibodies, and are considered to result from enhanced T helper type-2 (Th2) responses to allergens. A Th2 response is ch...
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Chapter
Gene immunization for allergic disorders
The allergic response is mediated by binding of allergens to specific IgE antibodies attached via IgE receptors to the surface of mast cells and basophils. The binding of allergens by surface IgE causes degran...
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Article
Gene immunization for allergic disorders
For immunotherapy to regain a major role as a treatment for allergic disorders, improvements in current allergen immunotherapy are needed to decrease treatment-associated risks when compared to the risks invol...
