5 Result(s)
within
David A Matthews
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessStructural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2
As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also di...
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Article
Virus genomes reveal factors that spread and sustained the Ebola epidemic
The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the reg...
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Article
Open AccessA comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus
The Ebola virus (EBOV) variant Makona (which emerged in 2013) was the causative agent of the largest outbreak of Ebola Virus Disease recorded. Differences in virus-host interactions between viral variants have...
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Article
Real-time, portable genome sequencing for Ebola surveillance
A nanopore DNA sequencer is used for real-time genomic surveillance of the Ebola virus epidemic in the field in Guinea; the authors demonstrate that it is possible to pack a genomic surveillance laboratory in ...
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Article
Open AccessTemporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.
