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  1. Article

    Open Access

    Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

    Aminoacyl-tRNA synthetases (ARSs) have evolved to acquire various additional domains. These domains allow ARSs to communicate with other cellular proteins in order to promote non-translational functions. Verte...

    Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun… in Nature Communications (2022)

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  2. Article

    Open Access

    PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair

    DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O6-methylguanine (O6meG)-DNA m...

    Jodie D. Cropper, Dauren S. Alimbetov… in Journal of Hematology & Oncology (2022)

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