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Article
An HSV vector system for selection of ligand-gated ion channel modulators
Pathological alterations of ion channel activity result from changes in modulatory mechanisms governing receptor biology. Here we describe a conditional herpes simplex virus (HSV) replication−based strategy to...
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Article
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IκBα and HSV thymidine kinase
To improve the effectiveness of herpes simplex virus (HSV) thymidine kinase/ganciclovir (HSV-tk/GCV) suicide gene therapy, the replication-defective HSV vector TOIκB expressing both HSV-TK and a mutant form of th...
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Protocol
Delivery of Herpes Simplex Virus-Based Vectors to the Nervous System
Gene transfer to the nervous system is an attractive option to treat a wide variety of neurological insults (1–3). The expression of trophic factor and/or antiapoptotic genes may be beneficial in halting the slow...
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Protocol
Gene Transfer to Glial Tumors Using Herpes Simplex Virus
Glial tumors occur as intraaxial masses in the brain and are uniformly fatal due to lack of effective therapy. Resection combined with radiation and chemotherapy fails to eradicate malignant cells infiltrating...
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Protocol
Delivery of Herpes Simplex Virus-Based Vectors to Stem Cells
In contrast to traditional drugs that generally act by altering existing gene product function, gene therapy aims to target the root cause of the disease by altering the genetic makeup of the cell to treat the...
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Protocol
Delivery Using Herpes Simplex Virus
The human herpesviruses represent excellent candidate viruses for several types of gene vector applications. As a class, they are large DNA viruses with the potential to accommodate large or multiple transgene...
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Article
Gene transfer of human manganese superoxide dismutase protects small intestinal villi from radiation injury
Small bowel toxicity represents a major dose-limiting side effect of radiation treatment for many malignancies. We examined the effects of overexpressing human manganese superoxide dismutase (MnSOD) in the sma...