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  1. No Access

    Article

    An HSV vector system for selection of ligand-gated ion channel modulators

    Pathological alterations of ion channel activity result from changes in modulatory mechanisms governing receptor biology. Here we describe a conditional herpes simplex virus (HSV) replication−based strategy to...

    Rahul Srinivasan, Shaohua Huang, Suchita Chaudhry, Adrian Sculptoreanu… in Nature Methods (2007)

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    Article

    Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IκBα and HSV thymidine kinase

    To improve the effectiveness of herpes simplex virus (HSV) thymidine kinase/ganciclovir (HSV-tk/GCV) suicide gene therapy, the replication-defective HSV vector TOIκB expressing both HSV-TK and a mutant form of th...

    Shusuke Moriuchi, Joseph C Glorioso, Motohiko Maruno… in Cancer Gene Therapy (2005)

  3. No Access

    Protocol

    Delivery of Herpes Simplex Virus-Based Vectors to the Nervous System

    Gene transfer to the nervous system is an attractive option to treat a wide variety of neurological insults (1–3). The expression of trophic factor and/or antiapoptotic genes may be beneficial in halting the slow...

    James R. Goss, Atsushi Natsume, Darren Wolfe… in Gene Delivery to Mammalian Cells (2004)

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    Protocol

    Gene Transfer to Glial Tumors Using Herpes Simplex Virus

    Glial tumors occur as intraaxial masses in the brain and are uniformly fatal due to lack of effective therapy. Resection combined with radiation and chemotherapy fails to eradicate malignant cells infiltrating...

    Ajay Niranjan, Darren Wolfe, Wendy Fellows… in Gene Delivery to Mammalian Cells (2004)

  5. No Access

    Protocol

    Delivery of Herpes Simplex Virus-Based Vectors to Stem Cells

    In contrast to traditional drugs that generally act by altering existing gene product function, gene therapy aims to target the root cause of the disease by altering the genetic makeup of the cell to treat the...

    Darren Wolfe, James B. Wechuck, David M. Krisky… in Gene Delivery to Mammalian Cells (2004)

  6. No Access

    Protocol

    Delivery Using Herpes Simplex Virus

    The human herpesviruses represent excellent candidate viruses for several types of gene vector applications. As a class, they are large DNA viruses with the potential to accommodate large or multiple transgene...

    William F. Goins, Darren Wolfe, David M. Krisky… in Gene Delivery to Mammalian Cells (2004)

  7. No Access

    Article

    Gene transfer of human manganese superoxide dismutase protects small intestinal villi from radiation injury

    Small bowel toxicity represents a major dose-limiting side effect of radiation treatment for many malignancies. We examined the effects of overexpressing human manganese superoxide dismutase (MnSOD) in the sma...

    Hong Liang Guo, Darren Wolfe, Michael W. Epperly… in Journal of Gastrointestinal Surgery (2003)