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Article
Open AccessImproving outcomes in atherosclerotic renovascular disease: importance of clinical presentation and multi-disciplinary review
Atherosclerotic renal artery stenosis may cause hypertension, chronic kidney disease and heart failure, but large randomized control trials to date have shown no major additional benefit of renal revasculariza...
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Article
Open AccessPredicting acute clinical deterioration with interpretable machine learning to support emergency care decision making
The emergency department (ED) is a fast-paced environment responsible for large volumes of patients with varied disease acuity. Operational pressures on EDs are increasing, which creates the imperative to effi...
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Article
Open AccessManaging acute presentations of atheromatous renal artery stenosis
Atherosclerotic renovascular disease (ARVD) often follows an asymptomatic chronic course which may be undetected for many years. However, there are certain critical acute presentations associated with ARVD and...
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Chapter
Disease of the Renal Vessels
Diseases of the renal vessels mainly involve stenosis of the main renal arteries which can lead to clinical presentations of hypertension, renal impairment and cardiac failure. The most common condition leadin...
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Article
Open AccessCommunity- versus hospital-acquired acute kidney injury in hospitalised COVID-19 patients
Acute kidney injury (AKI) is a recognised complication of coronavirus disease 2019 (COVID-19), yet the reported incidence varies widely and the associated risk factors are poorly understood.
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Article
Open AccessConsequences of the emergency response to COVID-19: a whole health care system review in a single city in the United Kingdom
The response to the COVID-19 pandemic in the United Kingdom included large scale changes to healthcare delivery, without fully understanding the potential for unexpected effects caused by these changes.
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Article
Open AccessA randomised controlled trial to examine the effects of cinacalcet on bone and cardiovascular parameters in haemodialysis patients with advanced secondary hyperparathyroidism
Secondary hyperparathyroidism may lead to increased cardiovascular risk. The use of cinacalcet may improve bone and cardiovascular health with improved parathormone (PTH) and phosphate control.
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Article
Open AccessSafely reducing haemodialysis frequency during the COVID-19 pandemic
Patients undergoing haemodialysis (HD) are at higher risk of develo** worse outcomes if they contract COVID-19. In our renal service we reduced HD frequency from thrice to twice-weekly in selected patients w...
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Article
Open AccessPredictive factors of rapid linear renal progression and mortality in patients with chronic kidney disease
Risk factors predictive of rapid linear chronic kidney disease (CKD) progression and its associations with end-stage renal disease (ESRD) and mortality requires further exploration, particularly as patients wi...
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Article
Open AccessCardiac structure and function after revascularization versus medical therapy for renal artery stenosis: the ASTRAL heart echocardiographic sub-study
The ASTRAL trial showed no difference in clinical outcomes between medical therapy and revascularization for atherosclerotic renal vascular disease (ARVD). Here we report a sub-study using echocardiography to ...
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Article
Open AccessCirculating proteins as predictors of cardiovascular mortality in end-stage renal disease
Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-assoc...
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Article
Open AccessComparing the impact of older age on outcome in chronic kidney disease of different etiologies: a prospective cohort study
In older patients with chronic kidney disease (CKD), the risk of progression to end stage renal disease and cardiovascular death both differ compared to younger patients. This likely reflects differences in ca...
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Article
Open AccessA narrative review of the impact of interventions in acute kidney injury
Acute kidney injury (AKI) is independently associated with significant morbidity and mortality, and is thus an important challenge facing physicians in modern healthcare. This narrative review assesses the imp...
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Article
Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation
The study objectives were to demonstrate that glycerol, when topically applied from a roll-on antiperspirant formulation, can be delivered directly to human skin ex vivo and the axillary stratum corneum (SC) i...
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Article
Open AccessEstimating renal function in old people: an in-depth review
Estimates of glomerular filtration rate (eGFR) should provide accurate measure of an individual’s kidney function because important clinical decisions such as timing of renal replacement therapy and drug dosin...
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Chapter
The Cardiac Impact of Atherosclerotic Renovascular Disease (ARVD)
Atherosclerotic renovascular disease (ARVD) typically occurs in the context of systemic atherosclerosis, hence patients with this condition usually have a high burden of coronary artery disease. In addition, n...
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Chapter
Sudden Cardiac Death in CKD and ESKD: Risk Factors, Mechanisms, and Therapeutic Strategies
Sudden cardiac death is a leading cause of death in end-stage kidney disease. Unlike in the general population, the predominant mechanism is thought not to be coronary atheroma but rather the uremic milieu and...
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Article
Open AccessThe importance of proteinuria and prior cardiovascular disease in all major clinical outcomes of atherosclerotic renovascular disease – a single-center observational study
Identification of patients at risk of develo** adverse events would enable aggressive medical therapy and possibly targeted revascularization. The aim of this study is to characterize the determinants of lon...
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Article
Speckle tracking determination of mitral tissue annular displacement: comparison with strain and ejection fraction, and association with outcomes in haemodialysis patients
Abnormal Global longitudinal strain (GLS) and reduced left ventricular ejection fraction (LVEF) are established poor prognostic risk factors in haemodialysis patients. Tissue motion annular displacement of mit...
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Article
Cardiac imaging in patients with chronic kidney disease
A number of available cardiac imaging tools provide information about cardiac structure and function in patients with renal disease
