-
Article
Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
-
Article
Open AccessAnalysis of cell free DNA to predict outcome to bevacizumab therapy in colorectal cancer patients
To predict outcome to combination bevacizumab (BVZ) therapy, we employed cell-free DNA (cfDNA) to determine chromosomal instability (CIN), nucleosome footprints (NF) and methylation profiles in metastatic colo...
-
Article
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
The circadian clock is the inner rhythm of life activities and is controlled by a self-sustained and endogenous molecular clock, which maintains a ~ 24 h internal oscillation. As the core element of the circad...
-
Article
Open AccessComplexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer
The histone deacetylase inhibitor (HDACi), belinostat, has had limited therapeutic impact in solid tumors, such as colon cancer, due to its poor metabolic stability. Here we evaluated a novel belinostat prodru...
-
Article
Author Correction: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
-
Article
Open AccessCopy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy
Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of bevacizumab (BVZ) response in ...
-
Protocol
Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology
The arraying of formalin-fixed paraffin-embedded (FFPE) tissue, or less commonly frozen tissue, in tissue microarrays (TMAs) is an invaluable method with which to assess the association of novel proteins with ...
-
Article
Open AccessIntegration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular...
-
Article
Open AccessA novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et ...
-
Article
Open AccessPeroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer
Peroxiredoxin-1 (PRDX1) is a multifunctional protein, acting as a hydrogen peroxide (H2O2) scavenger, molecular chaperone and immune modulator. Although differential PRDX1 expression has been described in many tu...
-
Article
Ghrelin concentrations in maternal and cord blood of Type 1 diabetic and non-diabetic pregnancies at term
-
Article
Open AccessMolecular correlates and prognostic significance of SATB1 expression in colorectal cancer
Special AT-rich sequence-binding protein 1 (SATB1) is a global gene regulator that has been reported to confer malignant behavior and associate with poor prognosis in several cancer forms. SATB1 expression has...
-
Article
Open AccessIdentification of a myometrial molecular profile for dystocic labor
The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium ...
-
Article
Open AccessTumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
We previously reported an association between tumor-specific 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) expression and a good prognosis in breast cancer. Here, the predictive value of HMG-CoAR...
-
Article
Open AccessValidation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
Conflicting data exist regarding the prognostic and predictive impact of survivin (BIRC5) in breast cancer. We previously reported survivin cytoplasmic-to-nuclear ratio (CNR) as an independent prognostic indic...
-
Article
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
Personalization of cancer therapy requires the identification of unambiguous diagnostic, prognostic and predictive biomarkers to facilitate the accurate strati...
-
Article
Open AccessExpression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 ...
-
Article
Open AccessTumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourab...
-
Article
A new effector pathway links ATM kinase with the DNA damage response
The related kinases ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) phosphorylate a limited number of downstream protein targets in response to DNA damage. Here we report a...
