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Article
Open AccessInhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions
The choice of targeted therapies for treatment of glioblastoma patients is currently limited, and most glioblastoma patients die from the disease recurrence. Thus, systematic studies in simplified model system...
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Article
The effect of substituents on carbon–carbon double bond isomerization in heterocyclic hydrazine derivatives
Even though enehydrazide moiety is present in many pharmaceuticals, there is currently no straightforward method available for preparing cyclic enehydrazides, which could be valuable building blocks in antican...
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Article
Open AccessViability fingerprint of glioblastoma cell lines: roles of mitotic, proliferative, and epigenetic targets
Despite the use of multimodal treatment combinations, the prognosis of glioblastoma (GB) is still poor. To prevent rapid tumor recurrence, targeted strategies for the treatment of GB are widely sought. Here, w...
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Article
Open AccessDecidualized endometrial stromal cells present with altered androgen response in PCOS
Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS endometrial stromal cells (eSCCtrl); however, this has not bee...
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Protocol
cAMP Biosensor Assay Using BacMam Expression System: Studying the Downstream Signaling of LH/hCG Receptor Activation
Cyclic adenosine monophosphate (cAMP) serves as a second messenger for numerous G-protein-coupled receptors. Changes in cellular cAMP levels reflect the biological activity of various GPCR-specific agents, inc...
