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  1. No Access

    Article

    Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer

    There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA), a highly lethal malignancy with increasing incidence1 and poor prognosis2. Although targeting tumour metabolism has been ...

    Min-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh… in Nature (2023)

  2. Article

    Open Access

    Critical role for arginase 2 in obesity-associated pancreatic cancer

    Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Despite recent identification of metabolic alterations in this lethal malignancy, the metabolic dependencies of obesity-associa...

    Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois… in Nature Communications (2017)

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  3. Article

    Open Access

    Starved epithelial cells uptake extracellular matrix for survival

    Extracellular matrix adhesion is required for normal epithelial cell survival, nutrient uptake and metabolism. This requirement can be overcome by oncogene activation. Interestingly, inhibition of PI3K/mTOR le...

    Taru Muranen, Marcin P. Iwanicki, Natasha L. Curry, Julie Hwang… in Nature Communications (2017)

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