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Article
Activation of homology-directed DNA repair plays key role in CRISPR-mediated genome correction
Gene editing for the cure of inborn errors of metabolism (IEMs) has been limited by inefficiency of adult hepatocyte targeting. Here, we demonstrate that in utero CRISPR/Cas9-mediated gene editing in a mouse mode...
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Article
Mitral Valve Endocarditis in a Pediatric Patient: When Is the Right Time to Intervene? A Case Report
Infective endocarditis (IE) is most often treated conservatively with medical management. There are no clear guidelines in the pediatric population for timing of surgical intervention. This is a case report of...
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Article
Open AccessZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
Reduced BRCA1 expression causes homologous recombination (HR) repair defects in high-grade serous ovarian cancers (HGSOCs). Here, we demonstrate that BRCA1 is transcriptionally activated by a previously unknown f...
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Article
Open AccessThe metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells
Mesenchymal stem cells (MSCs) perform paracrine functions by releasing extracellular vesicles (EVs) containing microRNA, mRNA, and proteins. We investigated the mRNA content of EVs in metabolic syndrome (MetS)...
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Article
Open AccessHGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data
Transfer of genetic material from microbes or viruses into the host genome is known as horizontal gene transfer (HGT). The integration of viruses into the human genome is associated with multiple cancers, and ...
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Article
Open AccessMAP-RSeq: Mayo Analysis Pipeline for RNA sequencing
Although the costs of next generation sequencing technology have decreased over the past years, there is still a lack of simple-to-use applications, for a comprehensive analysis of RNA sequencing data. There i...
