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Article
A community-driven global reconstruction of human metabolism
The metabolic modeling community has curated information from five models to create the most comprehensive model of human metabolism to date.
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Article
Open AccessSystematic integration of experimental data and models in systems biology
The behaviour of biological systems can be deduced from their mathematical models. However, multiple sources of data in diverse forms are required in the construction of a model in order to define its componen...
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Article
Open AccessFurther developments towards a genome-scale metabolic model of yeast
To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstructi...
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Chapter and Conference Paper
Integrative Information Management for Systems Biology
Systems biology develops mathematical models of biological systems that seek to explain, or better still predict, how the system behaves. In bottom-up systems biology, systematic quantitative experimentation i...
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Article
Open AccessInformation management for high content live cell imaging
High content live cell imaging experiments are able to track the cellular localisation of labelled proteins in multiple live cells over a time course. Experiments using high content live cell imaging will gene...
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Article
Open AccessData capture in bioinformatics: requirements and experiences with Pedro
The systematic capture of appropriately annotated experimental data is a prerequisite for most bioinformatics analyses. Data capture is required not only for submission of data to public repositories, but also...
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Article
The Relationship Between the Rate of Molecular Evolution and the Rate of Genome Rearrangement in Animal Mitochondrial Genomes
Evolution of mitochondrial genes is far from clock-like. The substitution rate varies considerably between species, and there are many species that have a significantly increased rate with respect to their clo...
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Article
The Evolution of tRNA-Leu Genes in Animal Mitochondrial Genomes
Animal mitochondrial genomes usually have two transfer RNAs for leucine: one, with anticodon UAG, translates the four-codon family CUN, while the other, with anticodon UAA, translates the two-codon family UUR....
