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Open AccessGenomic selection strategies for clonally propagated crops
For genomic selection in clonally propagated crops with diploid (-like) meiotic behavior to be effective, crossing parents should be selected based on genomic predicted cross-performance unless dominance is ne...
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Transcriptomic analysis of pollen-pistil interactions in almond (Prunus dulcis) identifies candidate genes for components of gametophytic self-incompatibility
The cultivated almond exhibits self-incompatibility of the gametophytic type regulated by the S-locus, which is expressed in both the pistil (S-RNase) and pollen (SFB protein). Although almond cultivars are mostl...
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Article
Open AccessIdentification of powdery mildew resistance QTL in strawberry (Fragaria × ananassa)
Key Message Powdery mildew resistance in two strawberry map** populations is controlled by both stable and transient novel QTL of moderate effect. Some low transferability o...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts
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Findings from the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group: the Power of Pooled Individual Patient Data from Multiple Clinical Trials
Randomized clinical trials (RCTs) are relied upon for determining the standard of care and changes to the standard of care in oncology. Through data sharing, the pooled individual patient data (IPD) from these...
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Open AccessGenoty**-by-sequencing in an orphan plant species Physocarpus opulifolius helps identify the evolutionary origins of the genus Prunus
The Rosaceae family encompasses numerous genera exhibiting morphological diversification in fruit types and plant habit as well as a wide variety of chromosome numbers. Comparative genomics between various Ros...
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Polyploid and aneuploid detection in apple using a single nucleotide polymorphism array
Polyploidisation is a common mechanism underlying genome evolution in plants. Both polyploid and aneuploid individuals occur naturally at low frequency in diploid species because of unbalanced or unreduced gam...
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Genotype-based clinical trials in cardiovascular disease
Substantial progress has been made in the field of pharmacogenomics, with advances in genoty** and sequencing technology, and by the routine collection of DN...
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Open AccessDevelopment and preliminary evaluation of a 90 K Axiom® SNP array for the allo-octoploid cultivated strawberry Fragaria × ananassa
A high-throughput genoty** platform is needed to enable marker-assisted breeding in the allo-octoploid cultivated strawberry Fragaria × ananassa. Short-read sequences from one diploid and 19 octoploid accession...
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Article
Shifting paradigms in cancer clinical trial design
Over the past decade, there have been profound shifts in clinical trial design. Phase II randomized studies, phase II/III and other adaptive designs, early surrogate end points, and prospective biomarker-based...
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Characterisation of the virescent locus controlling a recessive phenotype in apple rootstocks (Malus pumila Mill.)
Certain progenies of Malling apple rootstocks (Malus pumila) have been reported to segregate for a virescent trait: leaves are chlorotic at germination or bud break but turn green as the season progresses. The M4...
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Open AccessAn evaluation of the PacBio RS platform for sequencing and de novo assembly of a chloroplast genome
Second generation sequencing has permitted detailed sequence characterisation at the whole genome level of a growing number of non-model organisms, but the data produced have short read-lengths and biased geno...
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Drug rechallenge and treatment beyond progression—implications for drug resistance
Reuse of the same anticancer therapy following disease progression is often considered to be futile owing to drug resistance; however, many cancers show sensit...
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Open AccessThe IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 months) Regimen for Patients with Stage III Colon Cancer: Trial Design and Current Status
The International Duration Evaluation of Adjuvant Chemotherapy (IDEA) collaboration was established to prospectively combine and analyze data from several randomized trials conducted around the world to answer...
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Open AccessSaturated linkage map construction in Rubus idaeususing genoty** by sequencing and genome-independent imputation
Rapid development of highly saturated genetic maps aids molecular breeding, which can accelerate gain per breeding cycle in woody perennial plants such as Rubus idaeus (red raspberry). Recently, robust genoty**...
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Rosaceae conserved orthologous set (RosCOS) markers as a tool to assess genome synteny between Malus and Fragaria
Intertribal comparisons of genome synteny between phylogenetically distant genera in Rosaceae, such as Malus (apple) and Fragaria (strawberry), have previously been hampered by a lack of transferable markers that...
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Article
Open AccessDevelopment of a dense SNP-based linkage map of an apple rootstock progeny using the Malus Infinium whole genome genoty** array
A whole-genome genoty** array has previously been developed for Malus using SNP data from 28 Malus genotypes. This array offers the prospect of high throughput genoty** and linkage map development for any giv...
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Open AccessThe genome of woodland strawberry (Fragaria vesca)
The International Strawberry Sequencing Consortium reports the draft genome of the woodland strawberry (Fragaria vesca). The genome of this diploid species should serve as a reference genome for the Fragaria genu...
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Open AccessComparative analysis of rosaceous genomes and the reconstruction of a putative ancestral genome for the family
Comparative genome map** studies in Rosaceae have been conducted until now by aligning genetic maps within the same genus, or closely related genera and using a limited number of common markers. The growing ...
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Article
Failure of bevacizumab in early-stage colon cancer
A randomized phase III trial of patients with stage II and III colon cancer showed no benefit of adding bevacizumab to standard adjuvant oxaliplatin plus fluorouracil and leucovorin. Despite suggestive evidenc...
