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Article
Open AccessHip Fracture Risk After Treatment with Tramadol or Codeine: An Observational Study
Hip fractures among older people are a major public health issue, which can impact quality of life and increase mortality within the year after they occur. A recent observational study found an increased risk ...
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Article
Open AccessStroke Risk Among Non-Elderly Users of Haloperidol or First-Generation Antipsychotics vs Second-Generation Antipsychotics: A Cohort Study from a US Health Insurance Claims Database
Previous studies have reported an increased risk of stroke in patients taking antipsychotics. However, most of these studies have been conducted in the elderly population.
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Article
Open AccessUnderstanding patient journey in ulcerative colitis prior to biologic initiation: a 5-year exploration
There has been a more pronounced shift toward earlier, more aggressive therapies in Crohn’s disease than in ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health ...
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Article
Open AccessChanneling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen
Observational studies estimating severe outcomes for paracetamol versus ibuprofen use have acknowledged the specific challenge of channeling bias. A previous study relying on negative controls suggested that u...
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Article
Open AccessEvaluation of disability in patients exposed to fluoroquinolones
Fluoroquinolones are used for conditions including sinusitis, bronchitis, and urinary tract infections. It has been suggested that exposure to fluoroquinolones for these conditions is associated with disabilit...
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Article
Open AccessDevelo** Predictive Models to Determine Patients in End-of-Life Care in Administrative Datasets
In observational studies with mortality endpoints, one needs to consider how to account for subjects whose interventions appear to be part of ‘end-of-life’ care.
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Article
Open AccessAwareness of, and Compliance with, Domperidone Revised Labeling After a Risk-Minimization Activity in Europe
Risk-minimization measures (RMM), including label revisions were implemented in Europe for domperidone because of evidence of increased incidence of cardiac arrhythmia and sudden cardiac death. In accordance w...
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Article
Open AccessAll-cause mortality in patients with treatment-resistant depression: a cohort study in the US population
Treatment-resistant depression (TRD) may represent a substantial proportion of major depressive disorder (MDD); however, the risk of mortality in TRD is still incompletely assessed.
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Article
Open AccessChanneling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications
Over-the-counter analgesics such as paracetamol and ibuprofen are among the most widely used, and having a good understanding of their safety profile is important to public health. Prior observational studies ...
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Article
Open AccessImproving the Identification of Out-of-Hospital Sudden Cardiac Deaths in a General Practice Research Database
The ascertainment of sudden cardiac death (SCD) in electronic health databases is challenging.
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Open AccessRisk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study
Epidemiological studies have linked domperidone use with serious cardiac arrhythmias, including sudden cardiac death, but data on age, dose, and duration of use are limited.
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Article
Open AccessPrevalence of Chronic Metoclopramide Use and Associated Diagnoses in the US Pediatric Population
Metoclopramide is the only medication widely used to promote gastrointestinal motility in the USA. Despite its appreciable risk of central nervous system complications, it continues to be prescribed to childre...
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Article
Open AccessFidelity Assessment of a Clinical Practice Research Datalink Conversion to the OMOP Common Data Model
The unique structure and coding of the Clinical Practice Research Datalink (CPRD) presents challenges for epidemiologic analysis and for comparisons with other databases. To address this limitation we sought t...
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Article
Open AccessShop** Behavior for ADHD Drugs: Results of a Cohort Study in a Pharmacy Database
Attention-deficit hyperactivity disorder (ADHD) medications are subject to abuse, misuse, and diversion. Obtaining ADHD prescriptions from multiple prescribers or filled across multiple pharmacies, known as ‘d...
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Open AccessExposure to Oral Fluoroquinolones and the Risk of Retinal Detachment: Retrospective Analyses of Two Large Healthcare Databases
A recent Canadian case–control study reported a 4.5-fold increased risk of retinal detachment (RD) during oral fluoroquinolone use. Of the fluoroquinolone-exposed cases, 83 % were exposed to ciprofloxacin. We ...
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Article
Assessing Opioid Shop** Behaviour
Background: Risks of abuse, misuse and diversion of opioids are of concern. Obtaining opioid prescriptions from multiple prescribers, known as opioid shop**, is a way in which opioids may be ab...
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Article
Open AccessDose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States
Little data exist on how opioid doses vary with the length of exposure among chronic opioid users.
