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  1. Article

    Open Access

    Differential cortical layer engagement during seizure initiation and spread in humans

    Despite decades of research, we still do not understand how spontaneous human seizures start and spread – especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-elect...

    Pierre Bourdillon, Liankun Ren, Mila Halgren, Angelique C. Paulk in Nature Communications (2024)

  2. Article

    Open Access

    Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans

    Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgic...

    Boglárka Hajnal, Johanna Petra Szabó, Emília Tóth, Corey J. Keller in Scientific Reports (2024)

  3. Article

    Open Access

    The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex

    Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. ...

    Daniel Fabo, Virag Bokodi, Johanna-Petra Szabó, Emilia Tóth in Scientific Reports (2023)

  4. Article

    Open Access

    The sleep EEG envelope is a novel, neuronal firing-based human biomarker

    Sleep EEG reflects voltage differences relative to a reference, while its spectrum reflects its composition of various frequencies. In contrast, the envelope of the sleep EEG reflects the instantaneous amplitu...

    Péter P. Ujma, Martin Dresler, Péter Simor, Dániel Fabó in Scientific Reports (2022)

  5. Article

    Open Access

    Bursting of excitatory cells is linked to interictal epileptic discharge generation in humans

    Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interi...

    Katharina T. Hofer, Ágnes Kandrács, Kinga Tóth, Boglárka Hajnal in Scientific Reports (2022)

  6. Article

    Open Access

    Superficial Slow Rhythms Integrate Cortical Processing in Humans

    The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration of activity across cortical areas is mediated anatomically by associative connections...

    Mila Halgren, Daniel Fabó, István Ulbert, Joseph R. Madsen in Scientific Reports (2018)