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358 Result(s)
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Article
Open AccessEvolution and subfunctionalization of CIPK6 homologous genes in regulating cotton drought resistance
The occurrence of whole-genome duplication or polyploidy may promote plant adaptability to harsh environments. Here, we clarify the evolutionary relationship of eight GhCIPK6 homologous genes in upland cotton (Go...
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Open AccessIntegrative proteome and metabolome unveil the central role of IAA alteration in axillary bud development following top** in tobacco
Axillary bud is an important aspect of plant morphology, contributing to the final tobacco yield. However, the mechanisms of axillary bud development in tobacco remain largely unknown. To investigate this aspe...
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Open AccessResearch on distribution strategy of logistics enterprise alliance based on three-party evolution game
Currently, collaborative distribution models have not reached the optimal state of carbon emissions. The cost of additional low-carbon expenditures and the problem of carbon data verification have led to the l...
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Open AccessThymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers
The development of Type I photosensitizers (PSs) is of great importance due to the inherent hypoxic intolerance of photodynamic therapy (PDT) in the hypoxic microenvironment. Compared to Type II PSs, Type I PS...
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Open AccessMidbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice
The potential brain mechanism underlying resilience to socially transferred allodynia remains unknown. Here, we utilize a well-established socially transferred allodynia paradigm to segregate male mice into pa...
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Open AccessOxidative modification of miR-30c promotes cardiac fibroblast proliferation via CDKN2C mismatch
The response of cardiac fibroblast proliferation to detrimental stimuli is one of the main pathological factors causing heart remodeling. Reactive oxygen species (ROS) mediate the proliferation of cardiac fibr...
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Open AccessCircular single-stranded DNA as a programmable vector for gene regulation in cell-free protein expression systems
Cell-free protein expression (CFE) systems have emerged as a critical platform for synthetic biology research. The vectors for protein expression in CFE systems mainly rely on double-stranded DNA and single-st...
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Open AccessMetformin is a potential therapeutic for COVID-19/LUAD by regulating glucose metabolism
Lung adenocarcinoma (LUAD) is the most common and aggressive subtype of lung cancer, and coronavirus disease 2019 (COVID-19) has become a serious public health threat worldwide. Patients with LUAD and COVID-19...
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Open AccessradioGWAS links radiome to genome to discover driver genes with somatic mutations for heterogeneous tumor image phenotype in pancreatic cancer
Addressing the significant level of variability exhibited by pancreatic cancer necessitates the adoption of a systems biology approach that integrates molecular data, biological properties of the tumors, medic...
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Article
Open AccessDomain wall magnetic tunnel junction-based artificial synapses and neurons for all-spin neuromorphic hardware
We report a breakthrough in the hardware implementation of energy-efficient all-spin synapse and neuron devices for highly scalable integrated neuromorphic circuits. Our work demonstrates the successful execut...
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Open AccessTocilizumab is associated with reduced delirium and coma in critically ill patients with COVID-19
Recent preclinical studies demonstrate a direct pathological role for the interleukin-6 (IL-6) pathway in mediating structural and functional delirium-like phenotypes in animal models of acute lung injury. Toc...
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Open AccessA comprehensive benchmarking with interpretation and operational guidance for the hierarchy of topologically associating domains
Topologically associating domains (TADs), megabase-scale features of chromatin spatial architecture, are organized in a domain-within-domain TAD hierarchy. Within TADs, the inner and smaller subTADs not only m...
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Open AccessAspartame carcinogenic potential revealed through network toxicology and molecular docking insights
The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects and mechanisms of aspartame (l-α-aspartyl-l-phenylalanine methyl ester). Aspa...
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Open AccessAnthropometric and physiological profiles of highly trained sailors in various positions and levels
This study aimed to analyze anthropometric and physiological profiles of highly trained sailors and the differences between sailors regarding various training levels. Forty-two sailors (22 male, 22.4 ± 3.8 yea...
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Open AccessEffects of plyometric training on health-related physical fitness in untrained participants: a systematic review and meta-analysis
Plyometric training (PT) is an effective training method for improving physical fitness among trained individuals; however, its impact on health-related physical fitness in untrained participants remains ambig...
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Open AccessFused in sarcoma (FUS) inhibits milk production efficiency in mammals
Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establish...
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Open AccessJoint association of overweight/obesity, high electronic screen time, and low physical activity time with early pubertal development in girls: a case–control study
To examine the joint association of electronic screen time (EST), moderate-to-vigorous physical activity time (MVPA) and overweight/obesity with early pubertal development (EPD) in girls. A case–control study ...
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Open AccessCity level water withdrawal and scarcity accounts of China
In the context of China’s freshwater crisis high-resolution data are critical for sustainable water management and economic growth. Yet there is a dearth of data on water withdrawal and scarcity regardless of ...
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Open AccessPotassium humate supplementation improves photosynthesis and agronomic and yield traits of foxtail millet
Foxtail millet is a highly nutritious crop, which is widely cultivated in arid and semi-arid areas worldwide. Humic acid (HA), as a common plant growth regulator, is used as an organic fertilizer and feed addi...
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Open AccessA negative feedback loop between TET2 and leptin in adipocyte regulates body weight
Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine, functioning as an essential epigenetic regul...