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  1. Article

    Open Access

    Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

    Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapit...

    Dana M Niedowicz, Valerie L Reeves, Thomas L Platt… in Acta Neuropathologica Communications (2014)

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  2. No Access

    Article

    Calmodulin binding is dispensable for Rem-mediated Ca2+ channel inhibition

    GTPases of the Ras-related RGK family are negative regulators of high voltage-activated (HVA) Ca2+ channel activity. In this study, we examined the role of calmodulin (CaM) association in Rem-mediated Ca2+ channe...

    Robert N. Correll, Chunyan Pang, Dana M. Niedowicz… in Molecular and Cellular Biochemistry (2008)

  3. No Access

    Article

    The role of oxidative stress in diabetic complications

    The morbidity and mortality associated with diabetes is the result of the myriad complications related to the disease. One of the most explored hypotheses to explain the onset of complications is a hyperglycem...

    Dana M. Niedowicz, David L. Daleke in Cell Biochemistry and Biophysics (2005)