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  1. No Access

    Article

    Fine tuning the transcription of ldhA for d-lactate production

    Fine tuning of the key enzymes to moderate rather than high expression levels could overproduce the desired metabolic products without inhibiting cell growth. The aims of this investigation were to regulate ra...

    Li Zhou, Wei Shen, Dan-Dan Niu… in Journal of Industrial Microbiology & Biote… (2012)

  2. No Access

    Article

    Improvement of d-lactate productivity in recombinant Escherichia coli by coupling production with growth

    Coupling lactate fermentation with cell growth was investigated in shake-flask and bioreactor cultivation systems by increasing aeration to improve lactate productivity in Escherichia coli CICIM B0013-070 (ackA ...

    Li Zhou, Kang-Ming Tian, Dan-Dan Niu, Wei Shen, Gui-Yang Shi… in Biotechnology Letters (2012)

  3. No Access

    Article

    Evaluation of Genetic Manipulation Strategies on d-Lactate Production by Escherichia coli

    In order to rationally manipulate the cellular metabolism of Escherichia coli for d-lactate production, single-gene and multiple-gene deletions with mutations in acetate kinase (ackA), phosphotransacetylase (pta)...

    Li Zhou, Zhi-Rui Zuo, **an-Zhong Chen, Dan-Dan Niu, Kang-Ming Tian… in Current Microbiology (2011)