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    Article

    Conformational analysis of yvae peptide derivatives

    Active conformations of YVAE peptide derivatives that were competitive inhibitors of 3-hydroxy3-methylglutaryl–coenzyme A reductase (HMG–CoA reductase) were determined. A type I β-turn in N-terminuses of the s...

    V. V. Pak, D. Y. Kwon, L. M. Yun, A. Yili, H. A. Aisa in Chemistry of Natural Compounds (2012)

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    Isolation and Identification of Peptides from Soy 11S-Globulin with Hypocholesterolemic Activity

    A peptide with hypocholesterolemic activity was isolated by HPLC from the pepsin hydrolysate of 11S-globulin. Its molecular weight (755.2 Da) and amino-acid sequence (Ile-Ala-Val-Pro-Gly-Glu-Val-Ala) were esta...

    V. V. Pak, M. S. Koo, T. D. Kasymova, D. Y. Kwon in Chemistry of Natural Compounds (2005)

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    Structure—Activity Relationships of the Peptide Ile-Ala-Val-Pro and Its Derivatives Revealed Using the Semi-Empirical AM1 Method

    Several peptides with hypocholesterinemic properties were investigated in order to reveal structure-activity relationships. The semi-empirical AM1 method and molecular dynamics were used to determine common st...

    V. V. Pak, M. Koo, N. Lee, M. S. Kim, D. Y. Kwon in Chemistry of Natural Compounds (2005)

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    Structures of the Peptide Leu-Pro-Tyr-Pro and Its Derivatives and the Nicotinamide Part of NADPH by a Semi-Empirical PM3 Method

    The capability of peptides Leu-Pro-Tyr-Pro (LPYP), Leu-Pro-Tyr-Pro-Arg (LPYPR), and Ser-Pro-Tyr-Pro-Arg (SPYPR) to occupy the part of the binding site ascribed to NADPH in the active center of 3-hydroxy-3-meth...

    V. V. Pak, M. Ku, N. Li, M. S. Kim, T. D. Kasymova in Chemistry of Natural Compounds (2005)

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    Article

    Conformation Analysis of Ile-Ala-Val-Pro Peptide and Its Derivatives by Circular Dichroism

    Ile-Ala-Val-Pro as a hypocholesterolemic peptide was isolated from soybean protein. We have synthesized four peptides, Ile-Ala-Val-Pro-Gly-Glu-Val-Ala, Leu-Ile-Ala-Val-Pro-Gly-Glu-Val-Ala, Ile-Ala-Val-Pro-Thr-...

    V. V. Pak, M. S. Koo, D. Y. Kwon, T. D. Kasimova in Chemistry of Natural Compounds (2004)