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  1. No Access

    Article

    Prostate cancer: from the pathophysiologic implications of some genetic risk factors to translation in personalized cancer treatments

    Several pathologies affect human prostate, such as prostate cancer (PC), which is the most common non-skin malignant cancer in Western male populations. A complex interaction between genetic and environmental ...

    C R Balistreri, G Candore, D Lio, G Carruba in Cancer Gene Therapy (2014)

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    Article

    Pathological Implications of Th1/Th2 Cytokine Genetic Variants in Behçet’s Disease: Data from a Pilot Study in a Sicilian Population

    Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) see...

    L. Vaccarino, G. Triolo, A. Accardo-Palombo, L. Scola, M. Palmeri… in Biochemical Genetics (2013)

  3. No Access

    Article

    Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease

    Proinflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their high production have been shown to b...

    D Lio, F Licastro, L Scola, M Chiappelli, L M Grimaldi, A Crivello… in Genes & Immunity (2003)

  4. No Access

    Article

    Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population

    Classes I and II human leukocyte antigens (HLA) genes encode highly polymorphic heterodimeric glycoproteins involved in the control of immune responses. The HLA class I gene HFE seemingly no longer participate...

    D Lio, C R Balistreri, G Colonna-Romano, M Motta, C Franceschi… in Genes & Immunity (2002)

  5. No Access

    Article

    Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

    Ageing is characterized by a pro-inflammatory status, which could contribute to the onset of major age-related diseases. Thus, genetic variations in pro- or anti-inflammatory cytokines might influence successf...

    D Lio, L Scola, A Crivello, G Colonna-Romano, G Candore, M Bonafè… in Genes & Immunity (2002)

  6. No Access

    Chapter

    The Application of Cellular Tests in the Selection of Unrelated Donors for Bone Marrow Transplantation

    Bone marrow transplants from genotypically human leucocyte antigens (HLA) identical sibling donors have been used successfully to treat patients with haematological malignancies and bone marrow failures. Howev...

    M. Oudshoorn, J. J. Van Rood, D. Lio… in Immunogenetics: Advances and Education (1997)

  7. No Access

    Article

    Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study

    A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesi...

    V. Serretta, G. Corselli, B. Piazza, D. Lio, F. Gervasi, S. Salerno… in Urological Research (1993)