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  1. Article

    Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis

    The content of heparan sulphate is reduced in the endothelium under hyperglycaemic conditions and may contribute to the pathogenesis of atherosclerosis. Heparanase-1 (HPR1) specifically degrades heparan sulpha...

    G. Rao, H. G. Ding, W. Huang, D. Le, J. B. Maxhimer, A. Oosterhof… in Diabetologia (2011)

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    Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization

    Macroautophagy (autophagy), a process for lysosomal degradation of organelles and long-lived proteins, has been linked to various pathologies including cancer and to the cellular response to anticancer therapi...

    M. A. Qadir, B. Kwok, W. H. Dragowska, K. H. To… in Breast Cancer Research and Treatment (2008)

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    Robotically assisted small intestinal strictureplasty in dogs

    Robotically assisted surgery offers the advantages of improved dexterity and elimination of tremor over conventional laparoscopic surgery. There have been few studies to date, however, examining the role of ro...

    T. Sonoda, S. Lee, R. L. Whelan, D. Le, C. Foglia, M. Venturero… in Surgical Endoscopy (2007)

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    Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients

    Non-alcoholic steatohepatitis (NASH) is a major cause of liver disease in morbidly obese patients. Clinical predictors of NASH remain elusive, as do molecular mechanisms of pathogenesis.

    D. Le, D. Marks, E. Lyle, C. L. Corless, B. S. Diggs, B. A. Jobe… in Surgical Endoscopy (2007)

  5. Article

    Abstract

    Mike van der Wal, Scott A. Lang, Ray W. Yip… in Canadian Journal of Anaesthesia (1993)

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    A fast and robust unconstrained optimization method requiring minimum storage

    This paper describes a new unconstrained optimisation procedure employing conjugate directions and requiring only threen-dimensional vectors. The method has been tested for computational efficiency and stability ...

    D. Le in Mathematical Programming (1985)