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Neuroendokrine Neoplasien der Mamma
Neuroendokrine Neoplasien (NEN) der Mamma sind spezifische Tumorentitäten. Ihre Häufigkeit wird in der Literatur mit bis zu 5 % der malignen epithelialen Neoplasien der Mamma angegeben. Definiert sind NEN der ...
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Article
The search for the primary tumor in metastasized gastroenteropancreatic neuroendocrine neoplasm
Gastroenteropancreatic neuroendocrine tumors (NETs) often present as liver metastasis from a carcinoma of unknown primary. We recently showed that primary NETs from the pancreas, small intestine and stomach as...
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Article
Bedeutung der PET/CT für die Chirurgie neuroendokriner Neoplasien
Neuroendokrine Neoplasien (NEN) sind seltene Malignome mit unterschiedlichem Metastasierungsverhalten, die den endokrinen Zellen des Körpers entstammen und Somatostatinrezeptoren aufweisen. Die 68Ga-Somatostatinr...
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Article
Neuroendokrine Neoplasien des distalen Jejunums und Ileums
Neuroendokrine Neoplasien (NEN) des distalen Jejunums und Ileums leiten sich von den serotoninproduzierenden enterochromaffinen Zellen (EC-Zellen) ab. Aufgrund ihrer niedrigen proliferativen Aktivität und ihre...
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Article
Erratum to: The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours
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Article
Open AccessThe joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours
Peptide receptor radionuclide therapy (PRRNT) is a molecularly targeted radiation therapy involving the systemic administration of a radiolabelled peptide designed to target with high affinity and specificity ...
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Article
Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death
Pro-inflammatory cytokines play a crucial role in immune-mediated beta cell destruction, an essential mechanism in the pathogenesis of type 1 diabetes mellitus. Microarray analysis recently identified osteopro...
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Article
The Rap–B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells
Glucose and glucagon-like peptide-1 have been shown to activate extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase in beta cells. We examined the contributions of the small GTPases Rap a...
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Article
Elevated density and plasticity of nerve fibres in anal fissures
Neural proliferative processes are regarded as a contributing factor in chronic inflammatory diseases and chronic pain. To elucidate whether neural proliferations occur in tissues surrounding chronic anal fis...