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    Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model

    Limited pharmacokinetic (PK) and pharmacodynamic (PD) data are available to use in methadone dosing recommendations in pediatric patients for either opioid abstinence or analgesia. Considering the extreme inte...

    Feng Yang, ** Tong, D. Gail. McCarver… in Journal of Pharmacokinetics and Pharmacody… (2006)