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Article
Open AccessRetinoic acid related orphan receptor α is a genetic modifier that rescues retinal degeneration in a mouse model of Stargardt disease and Dry AMD
Degeneration of the macula is associated with several overlap** diseases including age-related macular degeneration (AMD) and Stargardt Disease (STGD). Mutations in ATP Binding Cassette Subfamily A Member 4 (AB...
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Article
Study the flow and species distribution characteristics in a typical 25-cell proton ceramic fuel cell stack by 3D large-scale modeling
Protonic ceramic fuel cell (PCFC) has attracted more and more research attention due to its special working features, compared with both the traditional oxygen ionic solid oxide fuel cell (O2−-SOFC) and protonic ...
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Article
Open AccessMultimodal Regulation Orchestrates Normal and Complex Disease States in the Retina
Regulation of biological processes occurs through complex, synergistic mechanisms. In this study, we discovered the synergistic orchestration of multiple mechanisms regulating the normal and diseased state (ag...
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Article
Open AccessThe Silk-protein Sericin Induces Rapid Melanization of Cultured Primary Human Retinal Pigment Epithelial Cells by Activating the NF-κB Pathway
Restoration of the retinal pigment epithelial (RPE) cells to prevent further loss of vision in patients with age-related macular degeneration represents a promising novel treatment modality. Development of RPE...
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Article
Erratum: Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin signaling
Correction to: Oncogene (2015) 34, 3188–3198; doi:10.1038/onc.2015.129; published online 20 April 2015 Post publication the author realised that some of the supplementary information had been incorrectly label...
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Article
Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin signaling
Cancer initiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial for self-renewal/differentiation of s...
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Article
Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors
The impact of activating KIR (aKIR) and inhibitory KIR (iKIR) on OS, relapse-related mortality (RRM) and acute GVHD (aGVHD) was prospectively studied in 84 adults with high-risk hematologic malignancies receiv...
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Article
Expression of γ-tocopherol methyltransferase gene from Brassica napus increased α-tocopherol content in soybean seed
A cDNA encoding γ-tocopherol methyltransferase from Brassica napus (BnTMT) was overexpressed in soybean [Glycine max (L.) Merr.] under the control of seed-specific promoter of Arabidopsis fatty acid elongase 1 (F...
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Article
Crystal structure and negative thermal expansion of solid solution Y2W3−xMoxO12
A new series of solid solutions Y2W3−xMoxO12 (0.5 ≤ x ≤ 2.5) were successfully synthesized by the solid state method. Their crystal structure and negative thermal expansion properties were studied using high-temp...
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Article
Open AccessReactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells
Experimental and clinical data support a growth inhibitory role for HER4 in breast cancer. Clinically HER4 expression is extinguished during breast tumorigenesis supporting a tumor suppressor function for HER4...
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Article
ISSR primer screening and preliminary evaluation of genetic diversity in wild populations of Gycyrrhiza uralensis
Fourteen efficient inter-simple sequence repeat (ISSR) primers were screened and optimized for detecting the genetic diversity in wild populations of Glycyrrhiza uralensis Fisch. By using these primers, 249 polym...
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Article
The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)
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Article
The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)
Natural killer (NK) cell alloreactions against recipient cells in the setting of bone marrow transplantation have been associated with decreased rates of graft-versus-host disease (GVHD) and improved survival ...
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Article
A distributed image-based virtual prototy** system with novel rendering tactics
Taking automobile design as a study case, this paper presents the approaches to implement a distributed image-based virtual prototy** (VP) system employing distributed virtual reality (DVR) technology combin...
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Article
β2-integrins mediate a novel form of chemoresistance in cycloheximide-induced U937 apoptosis
In this study with cycloheximide (CHX, an inhibitor of protein synthesis) and the human leukaemic cell line U937, a novel form of chemoresistance, which we termed sudden drug resistance (SDR), was identified u...
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Article
Manipulation of bioparticles using traveling wave dielectrophoresis: numerical approach
A typical microelectrode structure, interdigitated bar electrodes, has been developed for the selective manipulation and separation of bioparticles using traveling field dielectrophoresis effects under AC elec...
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Article
Reef-coral proteins as visual, non-destructive reporters for plant transformation
Recently, five novel fluorescent proteins have been isolated from non-bioluminescent species of reef-coral organisms and have been made available through ClonTech. They are AmCyan, AsRed, DsRed, ZsGreen and Zs...
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Article
MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry
The human major histocompatibility complex (MHC) class I chain-related gene A (MICA), located 46 kb centromeric to HLA-B, encodes a stress-inducible protein, which is a ligand for the NKG2D receptor. In additi...
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Article
Current and future neutron-scattering development in CIAE
Currently, the 15-MW Heavy Water Research Reactor (HWRR) at the China Institute of Atomic Energy (CIAE) in Bei**g is the only neutron source available for neutron-scattering experiments in China. A 60-MW tank...
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Article
Use of the GFP reporter as a vital marker for Agrobacterium-mediated transformation of sugar beet (Beta vulgaris L.)
Molecular approaches to sugar beet improvement will benefit from an efficient transformation procedure that does not rely upon exploitation of selectable marker genes such as those which confer antibiotic or h...
