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Reference Work Entry In depth
Pediatric Brain Tumors
Tumors of the central nervous system are the most common type of solid neoplasm found in children and are second only to leukemia in overall cancer frequency. Incidence is 2–5 in 100,000 with primary brain tum...
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Living Reference Work Entry In depth
Pediatric Brain Tumors
Tumors of the central nervous system are the most common type of solid neoplasm found in children and are second only to leukemia in overall cancer frequency. Incidence is 2–5 in 100,000 with primary brain tum...
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Article
Open AccessPre-operative neutrophil count and neutrophil-lymphocyte count ratio (NLCR) in predicting the histological grade of paediatric brain tumours: a preliminary study
The neutrophil-lymphocyte count ratio (NLCR) is an established prognostic marker for renal, lung and colorectal carcinomas and has been suggested to be predictive of histological grade and outcome in adult int...
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Article
Thinking outside the shunt—sterile CSF malabsorption in pilocytic astrocytomas: case series and review of the literature
Ventriculoperitoneal (VP) shunt insertion is the most common cerebrospinal fluid (CSF) diversionary procedure used for the treatment of chronic hydrocephalus. Sterile CSF ascites is a rare complication of VP s...
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Article
Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells
Oligodendrogliomas may be divided into those with deletion of chromosomes 1p and 19q (Del+), and those without (Del−). Del+ tumours show better survival and chemoresponsiveness but the reason for this differen...
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Article
Open AccessDNA replication licensing and cell cycle kinetics of oligodendroglial tumours
The convergence point of growth-signalling pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly of pre-replicative complexes (pre-RCs), resulting ...
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Article
Detection of a novel missense mutation and second recurrent mutation in the CACNA1A gene in individuals with EA-2 and FHM
Mutations in the brain specific P/Q type Ca2+ channel alpha1 subunit gene, CACNA1A, have been identified in three clinically distinct disorders, viz. episodic ataxia type 2 (EA-2), familial hemiplegic migraine (...