18 Result(s)

Article

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders

Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that may share an underlying pathology suggested by shared genetic risk variants. We sequenced the exonic region...

E M Kenny, P Cormican, S Furlong, E Heron, G Kenny, C Fahey… in Molecular Psychiatry (2014)

Article

Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene

Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, ...

X-j Luo, M Li, L Huang, S Steinberg, M Mattheisen, G Liang… in Molecular Psychiatry (2014)

Article

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have reinforced the hypothesis that rare geneti...

S E McCarthy, J Gillis, M Kramer, J Lihm, S Yoon, Y Berstein… in Molecular Psychiatry (2014)

Article

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility

Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some vari...

M Li, X-j Luo, M Rietschel, C M Lewis, M Mattheisen… in Molecular Psychiatry (2014)

Article

Promoter polymorphisms in two overlap** 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia

In a previous study, we detected a 6p25–p24 region linked to schizophrenia in families with high composite cognitive deficit (CD) scores, a quantitative trait integrating multiple cognitive measures. Associati...

A Jablensky, D Angelicheva, G J Donohoe, M Cruickshank, D N Azmanov… in Molecular Psychiatry (2012)

Article

ZNF804A and social cognition in patients with schizophrenia and healthy controls

A Hargreaves, D W Morris, E Rose, C Fahey, S Moore, E Cummings… in Molecular Psychiatry (2012)

Article

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic as...

X Chen, G Lee, B S Maher, A H Fanous, J Chen, Z Zhao, A Guo… in Molecular Psychiatry (2011)

Article

Fine map** of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder

A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10⁻⁷), and stronger evidence when t...

H J Williams, N Norton, S Dwyer, V Moskvina, I Nikolov, L Carroll… in Molecular Psychiatry (2011)

Article

Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha

We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and p...

L S Carroll, N M Williams, V Moskvina, E Russell, N Norton… in Molecular Psychiatry (2010)

Article

Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide p...

M C O'Donovan, N Norton, H Williams, T Peirce, V Moskvina… in Molecular Psychiatry (2009)

Article

DAOA ARG30LYS and verbal memory function in schizophrenia

G Donohoe, D W Morris, I H Robertson, K A McGhee, K Murphy, N Kenny… in Molecular Psychiatry (2007)

Article

Confirmation and refinement of an ‘at-risk’ haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus

Two recent association studies have implicated the neuregulin-1 gene (NRG1) at chromosome 8p21–22 as a susceptibility gene for schizophrenia. Stefansson et al identified three ‘at-risk’ haplotypes (HapA, B and C)...

A P Corvin, D W Morris, K McGhee, S Schwaiger, P Scully, J Quinn… in Molecular Psychiatry (2004)

Article

Linkage disequilibrium map** provides further evidence of a gene for reading disability on chromosome 6p21.3–22

Linkage disequilibrium (LD) map** was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3–22. Using a two-stage approach, we tested for association b...

D Turic, L Robinson, M Duke, D W Morris, V Webb, M Hamshere… in Molecular Psychiatry (2003)