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  1. Article

    AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

    Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. Oligomerisation of initiating proteins ...

    V Sagulenko, S J Thygesen, D P Sester, A Idris… in Cell Death & Differentiation (2013)

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    Macrophage Activation by Immunostimulatory DNA

    Activation of macrophages/dendritic cells appears to be of crucial importance in vivo in immunostimulation by foreign DNA. Immune cell activation by bacterial DNA was first observed using mixed spleen cell cul...

    K. J. Stacey, D. P. Sester, M. J. Sweet, D. A. Hume in Immunobiology of Bacterial CpG-DNA (2000)