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Article
Open AccessThe Infarct-Limiting Effect of Remote Ischemic Conditioning in Rats Is Not Affected by Aspirin
Remote ischemic conditioning (RIC) has been shown to be a powerful cardioprotective therapy in animal models. However, a protective effect in patients presenting with acute myocardial infarction has failed to ...
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Article
Open AccessRemote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop
The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemi...
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Open AccessCorrection: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
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Article
Open AccessTargeting myocardial ischaemic injury in the absence of reperfusion
Sudden myocardial ischaemia causes an acute coronary syndrome. In the case of ST-elevation myocardial infarction (STEMI), this is usually caused by the acute rupture of atherosclerotic plaque and obstruction o...
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Article
Open AccessIntrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning
This study aimed to investigate the role of the intrinsic cardiac nervous system in the mechanism of classical myocardial ischaemic preconditioning (IPC). Isolated perfused rat hearts were subjected to 35-min ...
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Article
Open Access9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection
In the 30 years since the original description of ischaemic preconditioning, understanding of the pathophysiology of ischaemia/reperfusion injury and concepts of cardioprotection have been revolutionised. In t...
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Article
Open AccessHearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as th...
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Article
Open AccessExogenous SDF-1α Protects Human Myocardium from Hypoxia-Reoxygenation Injury via CXCR4
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Open AccessCardioprotective Properties of the Platelet P2Y12 Receptor Inhibitor, Cangrelor: Protective in Diabetics and Reliant Upon the Presence of Blood
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Article
Open AccessDJ-1 protects against cell death following acute cardiac ischemia–reperfusion injury
Novel therapeutic targets are required to protect the heart against cell death from acute ischemia–reperfusion injury (IRI). Mutations in the DJ-1 (PARK7) gene in dopaminergic neurons induce mitochondrial dysf...
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Article
The Mitochondrial Permeability Transition Pore as a Target for Cardioprotection in Hypertrophic Cardiomyopathy
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Investigating the Signal Transduction Pathways Underlying Remote Ischemic Conditioning in the Porcine Heart
The mechanism underlying remote ischemic conditioning (RIC) remains unclear. We investigated whether RIC protects the heart through the activation of the adenosine receptor and the PI3K-Akt pathway at the onse...
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Article
The Cardioprotective Effect of Necrostatin Requires the Cyclophilin-D Component of the Mitochondrial Permeability Transition Pore
Necrostatin (Nec-1) protects against ischemia–reperfusion (IR) injury in both brain and heart. We have previously reported in this journal that necrostatin can delay opening of the mitochondrial permeability t...
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Article
Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo
Erythropoietin (EPO) is a hormone that is currently used to treat patients with renal failure and anaemia. However, it has also been shown to protect against ischaemia/reperfusion injury; this protection occur...
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Open AccessRepresentational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart
Preconditioning of the myocardium rapidly induces a number of transcription factors, which are likely to be responsible for a cascade of transcriptional changes underlying the development of delayed adaptation...
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Omapatrilat Limits Infarct Size and Lowers the Threshold for Induction of Myocardial Preconditioning Through a Bradykinin Receptor-Mediated Mechanism
Bradykinin is an important endogenous trigger of myocardial ischemic preconditioning (IPC). Through simultaneous inhibition of neutral endopeptidase and angiotensin converting enzyme, omapatrilat prevents enzy...
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Article
Adenosine A1 Agonist at Reperfusion Trial (AART): Results of a Three-Center, Blinded, Randomized, Controlled Experimental Infarct Study
Adenosine A1 receptor agonists given prior to myocardial ischemia limit ischemic injury in several species. However, the ability of adenosine receptor agonists to limit infarct size when given at reperfusion has ...
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Article
Enhanced Protection of Heat Shock in Myocardial Infarction: Inhibition of Detrimental Effect of Systemic Hyperthermia
Summary. We have shown that isolated blood-perfused heat-stressed hearts are protected only when the blood donor animal has not been exposed to hyperthermia. Systematic hyperthermia results in larger infarctio...
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Heat Stress Proteins and Their Relationship to Myocardial Protection
Acute myocardial infarction is the most common cause of death in men in the Western world. The treatment of this condition is no longer simply supportive, awaiting the complications of ischaemic injury, but ha...
