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Article
Open AccessUnderstanding of BRCA VUS genetic results by breast cancer specialists
Mainstreaming genetic medicine, increased media coverage and clinical trials for BRCA mutation carriers are leading oncologists into more patient discussions about BRCA genetic testing. BRCA variants of uncertain...
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Article
Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02)
Although there have been encouraging recent studies showing a potential benefit from annual mammography in women aged 40–49 years of age with an elevated breast cancer risk due to family history there is littl...
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Article
Open AccessErratum: The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
Correction to: British Journal of Cancer (2008) 98, 1457–1466. doi:10.1038/sj.bjc.6604305 Owing to an error on the part of the authors, co-author Barbara Pasini's surname was incorrectly submitted to the journ...
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Article
Open AccessThe BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2,...
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Article
Open AccessDosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification
Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for detecting gross deletions or duplications of DNA sequences, aberrations which are commonly overlooked by standard diag...
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Article
Open AccessApoptosis, ageing and cancer susceptibility
We have previously shown that peripheral blood lymphocytes (PBL) from individuals carrying a germline TP53 mutation show a dramatically reduced apoptotic response to radiation. As part of a study of this phenomen...
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Article
Open AccessMinisatellite instability is found in colorectal tumours with mismatch repair deficiency
Microsatellite instability (MSI) in colorectal tumours is demonstrated by PCR amplification of several different microsatellite loci. Minisatellites, which are repeats of longer sequences also found throughout...
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Allele losses on chromosome 17 in ovarian tumours
Analysis of tumours for localized loss of heterozygosity (LOH) or ‘allele imbalance’ is a well-recognized approach to the detection and map** of tumour suppressor genes [1]. Studies in ovarian cancer have id...
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Article
Mitozantrone and prednimustine in the treatment of advanced breast cancer — a toxic regimen with low activity
The combination of mitozantrone and prednimustine has been reported to elicit response rates of around 50% in patients with advanced breast cancer. In the present trial, either three or nine courses of this co...
