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  1. Article

    Open Access

    Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers

    Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheles...

    K. Louault, T. L Bonneaud, C. Séveno, P. Gomez-Bougie, F. Nguyen, F. Gautier… in Oncogene (2019)

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  2. No Access

    Article

    Prognostic and therapeutic factors of gliosarcoma from a multi-institutional series

    The aims of this multicentre retrospective study were to identify prognostic or therapeutic factors impacting on overall survival in patients with gliosarcoma. The analysis included all patients treated for gl...

    J. Castelli, L. Feuvret, Q. C. Haoming, J. Biau, E. Jouglar… in Journal of Neuro-Oncology (2016)

  3. No Access

    Article

    Combining two biomarkers, IDH1/2 mutations and 1p/19q codeletion, to stratify anaplastic oligodendroglioma in three groups: a single-center experience

    IDH1/2 mutations and 1p/19q codeletion occur frequently in anaplastic gliomas and are prognostic factors. We combined these two biomarkers to stratify patients treated for anaplastic oligodendroglioma (AO). 43...

    J. S. Frenel, C. Leux, D. Loussouarn, A.-G. Le Loupp… in Journal of Neuro-Oncology (2013)

  4. Article

    Open Access

    Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme

    Apoptosis has a crucial role in anti-cancer treatment. The proteins of the BCL-2 family are core members of the apoptotic program. Thus, we postulated that alterations in the expression of BCL-2 protein family...

    P F Cartron, D Loussouarn, M Campone, S A Martin, F M Vallette in Cell Death & Disease (2012)

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  5. Article

    Open Access

    Validation of UBE2C protein as a prognostic marker in node-positive breast cancer

    We recently identified and validated UBE2C RNA as a prognostic marker in 252 node-positive (N+) breast cancers by means of a microarray study. The aim of this study was to validate UBE2C protein as a prognostic m...

    D Loussouarn, L Campion, F Leclair, M Campone, C Charbonnel… in British Journal of Cancer (2009)

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  6. Article

    Open Access

    Prognostic impact of syndecan-1 expression in invasive ductal breast carcinomas

    Carcinoma cells lack syndecan-1 expression when they are transiting from an epithelial to a less-differentiated mesenchymal phenotype (epithelial–mesenchymal transition, EMT). Furthermore, a shift of syndecan-...

    D Loussouarn, L Campion, C Sagan, J-S Frenel, F Dravet… in British Journal of Cancer (2008)

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  7. No Access

    Article

    Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients’ survival in glioblastoma multiforme

    Prostaglandin E2 plays multiple roles both in the physiology and the physiopathology of human brain, which are not completely understood. We have identified in a subset of human glioblastoma multiforme (GBM) tumo...

    L Lalier, P-F Cartron, F Pedelaborde, C Olivier, D Loussouarn, S A Martin… in Oncogene (2007)