44 Result(s)

Article

Association Between Systemic Inflammation, Carotid Arteriosclerosis, and Autonomic Dysfunction

Systemic inflammation is associated with arteriosclerotic disease progression and worse stroke outcome in patients with carotid arteriosclerotic disease. We hypothesize that systemic inflammation is mediated b...

Sven Rupprecht, S. Finn, D. Hoyer, A. Guenther… in Translational Stroke Research (2020)

Article

Diurnal variations of short-term variation and the impact of multiple recordings on measurement accuracy

Short-term variation (STV) from computerized cardiotocogram heart rate analysis is a parameter that complements decision making, regarding the delivery of fetuses in several high-risk situations. Although stud...

G Seliger, D Petroff, S Seeger, D Hoyer, M Tchirikov… in Journal of Perinatology (2017)

Chapter and Conference Paper

Fetal Development, Nonlinear Heart Rate Dynamics, and Self-Organization

Background: The fetal precursors of mental and cardiovascular disease in later age are an important issue of developmental medicine. We investigate the question whether key parameters of fetal development refl...

D. Hoyer, U. Schneider in World Congress on Medical Physics and Biom… (2010)

Chapter and Conference Paper

Heart Rate Variability Approaches to Cholinergic Alterations in Neuropsychiatric Disorders

Both, major depression and schizophrenia, are associated with a cholinergic autonomic dysfunction. Based on previous studies we investigated the hypothesis, that this aspect of neuropsychiatric disorders can b...

D. Hoyer, K. J. Bär in World Congress on Medical Physics and Biom… (2010)

Chapter and Conference Paper

Identification of fetal auditory evoked cortical responses using a denoising method based on periodic component analysis

The analysis of auditory evoked cortical responses in the MEG of preterm neonates may result in early markers of functional cerebral development. A major constraint to this approach is the very low signal-to-n...

Liviu Moraru, R. Sameni, U. Schneider… in 4th European Conference of the Internation… (2009)

Article

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN08...

M Fendt, S Schmid, D R Thakker, L H Jacobson, R Yamamoto… in Molecular Psychiatry (2008)

Article

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

The significant proportion of depressed patients that are resistant to monoaminergic drug therapy and the slow onset of therapeutic effects of the selective serotonin reuptake inhibitors (SSRIs)/serotonin/nora...

B Conti, R Maier, A M Barr, M C Morale, X Lu, P P Sanna, G Bilbe… in Molecular Psychiatry (2007)

Article

Permutation entropy improves fetal behavioural state classification based on heart rate analysis from biomagnetic recordings in near term fetuses

The relevance of the complexity of fetal heart rate fluctuations with regard to the classification of fetal behavioural states has not been satisfyingly clarified so far. Because of the short behavioural state...

B. Frank, B. Pompe, U. Schneider, D. Hoyer in Medical and Biological Engineering and Com… (2006)

Article

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

D R Thakker, F Natt, D Hüsken, H van der Putten, R Maier, D Hoyer… in Molecular Psychiatry (2005)

Article

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressant drugs that increase the extracellular levels of serotonin by blocking the reuptake activity of the serotonin transporter (SERT). A...

D R Thakker, F Natt, D Hüsken, H van der Putten, R Maier, D Hoyer… in Molecular Psychiatry (2005)

Article

Autonome Funktionen beim Gesunden Autonome Steuerung von Herzkreislauf- und Lungenfunktion und deren Koordination

Neben der bekannten vertikalen Struktur des autonomen Systems mit sympathischen und parasympathischen Komponenten sind horizontale Regulationsebenen von wesentlicher funktioneller Bedeutung. Sie sind sowohl hi...

U. Zwiener, D. Hoyer, C. Wicher, H. Hardraht in Der Internist (2002)

Chapter

Synthesis and Biological Evaluation of Mixed β²/β³-Dipeptides as Somatostatin Analogs

Somatostatin (somatotropin release-inhibiting factor, SRIF) is a widely distributed tetradecapeptide with multiple functions, including modulation of secretion of growth hormone, insulin, glucagon, and gastric...

T. Kimmerlin, D. Hoyer, D. Seebach in Peptides: The Wave of the Future (2001)

Article

Kardiorespiratorische Desynchronisation nach akutem Myokardinfarkt

The prognosis of cardiac diseases can be estimated from the variability of regulation parameters of the cardiovascular system. Changes in the variability of a regulation parameter causes disturbances in the sy...

U. Leder, D. Hoyer, M. Sommer, V. Baier, J. Haueisen… in Zeitschrift für Kardiologie (2000)

Article

Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D₄ receptor

It has been difficult to observe functional coupling of the D₄ receptor to second messenger systems and a robust functional assay system for this receptor is still lacking. In the present study, the rat dopamine...

L. Gazi, P. Schoeffter, C. Nunn, K. Croskery… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2000)

Chapter

5-Hydroxytryptamine Receptor Histochemistry: Comparison of Receptor mRNA Distribution and Radioligand Autoradiography in the Brain

Understanding neurotransmission begins with the anatomical and cellular localisation of neurotransmitters and their receptors. Ideally the question to be answered is: which neurone contains which receptor, and...

G. Mengod, J. M. Palacios, K. H. Wiederhold… in Serotoninergic Neurons and 5-HT Receptors … (2000)

Article

Characterisation of human recombinant somatostatin receptors. 2. Modulation of GTPγS binding

G protein activation by somatostatin (somatotropin release inhibiting factor, SRIF), cortistatin (CST) and analogues of these neuropeptides was investigated at human somatostatin receptor subtypes 1–5 (sst_1–5) s...

S. Siehler, D. Hoyer in Naunyn-Schmiedeberg's Archives of Pharmacology (1999)

Article

Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity

Total [³H]phosphoinositide (IP_x) accumulation, a measure of phospholipase C (PLC) activity, induced by somatostatin (somatotropin release-inhibiting factor, SRIF) and cortistatin (CST) analogues was studied at h...

S. Siehler, D. Hoyer in Naunyn-Schmiedeberg's Archives of Pharmacology (1999)

Article

Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies

Human somatostatin receptor subtypes 1–5 (sst_1–5) were characterised using the agonist radioligands [¹²⁵I]LTT-SRIF₂₈, [¹²⁵I][Tyr¹⁰]CST₁₄, [¹²⁵I]CGP 23996 and [¹²⁵I][Tyr³]octreotide in stably transfected Chinese ...

S. Siehler, K. Seuwen, D. Hoyer in Naunyn-Schmiedeberg's Archives of Pharmacology (1999)

Article

Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity

The five human somatostatin receptor subtypes (hsst_1–5) were stably expressed in CCL39 cells (Chinese hamster lung fibroblast cells) to study the inhibition of forskolin-stimulated adenylate cyclase (FSAC) activ...

S. Siehler, D. Hoyer in Naunyn-Schmiedeberg's Archives of Pharmacology (1999)