8 Result(s)
-
Article
Open AccessBreast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants
To improve breast cancer risk stratification to enable more targeted early detection/prevention strategies that will better balance risks and benefits of population screening programmes.
-
Article
Open AccessPARP inhibitors in platinum-sensitive high-grade serous ovarian cancer
Poly(ADP-ribose) polymerase inhibitors (PARPi) have changed the management of high-grade serous ovarian cancer (HGSOC). The rationale for the development of PARPi was based on the concept of synthetic lethalit...
-
Article
Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral
The aim of this study was to establish if risk-reducing surgery (RRS) increases survival among BRCA1/2 carriers without breast/ovarian cancer at the time of family referral. Female BRCA1/2 carriers were identifie...
-
Article
Contralateral mastectomy improves survival in women with BRCA1/2-associated breast cancer
BRCA1/2 mutation carriers with breast cancer are at high risk of contralateral disease. Such women often elect to have contralateral risk-reducing mastectomy (CRRM) to reduce the likelihood of re...
-
Article
High sensitivity for BRCA1/2 mutations in breast/ovarian kindreds: are there still other breast/ovary genes to be discovered?
-
Article
Mechanisms of Disease: prediction and prevention of breast cancer—cellular and molecular interactions
Breast cancer is a multifactorial condition, and changes in cellular biology are affected by a large number of variables known to affect an individual's susceptibility to this malignancy. Current risk predicti...
-
Article
Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer
The molecular basis for most non-HNPCC familial colorectal cancer cases is unknown, but there is increasing evidence that common genetic variants may play a role. We investigated the contribution of polymorphi...
-
Article
Relative frequency and morphology of cancers in carriers of germline TP53 mutations
The spectrum and frequency of cancers associated with germline TP53 mutations are uncertain. To address this issue a cohort of individuals from 28 families with Li-Fraumeni syndrome, segregating germline TP53 ...
