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Article
‘Real-life’ report on the management of chronic GvHD in the Gruppo Italiano Trapianto Midollo Osseo (GITMO)
Several guidelines have been published about management of chronic GvHD (cGvHD), but the clinical practice still remains demanding. The Gruppo Italiano Trapianto di Midollo Osseo (GITMO) has planned a prospect...
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Article
Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000–2010
Allogeneic hemopoietic stem cell transplantation (HSCT) is the only method currently available to cure transfusion-dependent thalassemia major that has been widely used worldwide. To verify transplantation dis...
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Article
Safety of hematopoietic stem cell donation in glucose 6 phosphate dehydrogenase-deficient donors
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common RBC enzymatic disorder in humans capable of producing hemolytic events. Recently, concern has been raised about using G6PD-deficienct subj...
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Article
Allogeneic transplantation following a reduced-intensity conditioning regimen in relapsed/refractory peripheral T-cell lymphomas: long-term remissions and response to donor lymphocyte infusions support the role of a graft-versus-lymphoma effect
Rescue chemotherapy or autologous stem cell transplantation (autoSCT) gives disappointing results in relapsed peripheral T-cell lymphomas (PTCLs). We have retrospectively evaluated the long-term outcome of 52 ...
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Article
Fate of chronic myeloid leukemia patients treated with allogeneic bone marrow transplantation or chemotherapy and/or interferon at a single center: long-term results
From April 1981 to February 2000, 105 patients with chronic myeloid leukemia (CML) underwent BMT from HLA-identical related donors at a single center. Eighty-eight patients were in chronic phase (CP), 11 patie...
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Article
A three or more drug combination as effective therapy for moderate or severe chronic graft-versus-host disease
We analyzed the results of a three or more drug combination as treatment for moderate or severe cGVHD develo** after transplantation for thalassemia, in 45 patients with median age of 11 (range 2–26) years. ...
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Article
Trichosporon beigelii: a life-threatening pathogen in immunocompromised hosts
Patients undergoing bone marrow transplantation are profoundly immunosuppressed as a result of their intensive myeloablative chemotherapy and are at high risk for opportunistic fungal infections mainly caused ...
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Article
Bone marrow transplantation from alternative donors for thalassemia: HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplants
Twenty-nine patients with thalassemia and a median age of 6 years (range 1.1–33 years) were given a BMT from an alternative donor. Six of the 29 donors were HLA-phenotypically identical and two were mismatched...
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Article
Second marrow transplants for graft failure in patients with thalassemia
Thirty-two thalassemic patients with a median age of 7.7 years (range 3.4–26 years) were given a second HLA-identical related marrow transplant (BMT2) for graft failure. Four patients were in class 1 and 28 pa...
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Article
Bone marrow transplantation for transfused patients with severe aplastic anemia using cyclophosphamide and total lymphoid irradiation as conditioning therapy: long-term follow-up from a single center
In transfused patients with aplastic anemia, incidence of graft rejection remains significant. Seventeen transfused patients with severe aplastic anemia received BMT from HLA-identical sibling donors after con...
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Article
FACTORS ASSOCIATED WITH SUCCESSFUL HUMAN MILK FEEDING OF VLBW NEWBORNS IN THE NICU
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Article
An unusual marrow transplant complication: cardiac myxoma
We report a right atrial myxoma which suddenly developed in a thalassemic patient after allogeneic bone marrow transplantation. The tumor was first detected by echocardiography on day +47 after transplant and ...
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Article
Relationship of plasma pharmacokinetics of high-dose oral busulfan to the outcome of allogeneic bone marrow transplantation in children with thalassemia
We analyzed plasma pharmacokinetics of busulfan in 64 children and young adults (age 2.8–26; median 11 years) with homozygous β-thalassemia transplanted with bone marrow from HLA-identical sibling donors. A unifo...
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Article
α-Interferon treatment of chronic hepatitis C after bone marrow transplantation for homozygous β-thalassemia
No experience has been reported to date in treating chronic hepatitis C virus (HCV) infection with interferon (IFN) therapy after BMT, mainly due to concerns related to the impact of an immunomodulatory drug i...
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Article
Kaposi’s sarcoma after allogeneic bone marrow transplantation
A case of Kaposi’s sarcoma (KS) in an allogenic BMT recipient is reported. A 26-year-old man underwent allogeneic bone marrow transplantation for microdrepanocytosis. He received prolonged immunosuppressive th...
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Chapter
Pancreatic beta-Cell Function Before and After Bone Marrow Transplantation for Thalassemia
Diabetes mellitus and impaired glucose tolerance are complications of thalassemic major patients treated by hypertransfusion schemes and chelation therapy. Diabetes in thalassemic patients seems to be the cons...
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Article
Pubertal development in thalassaemic patients after allogenic bone marrow transplantation
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Article
Pubertal development in thalassaemic patients after allogenic bone marrow transplantation
To obtain further insight into gonadal function, a series of 50 prepubertal patients with β-thalassaemia major (24 boys and 26 girls) aged from 12.6 to 18 years (mean 15 years) who had received a bone marrow t...
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Article
Bone marrow transplantation for thalassemia
Early trials of allogeneic bone marrow transplantation (BMT) for homozygous beta-thalassemia and the analyses of results of transplantation in patients less then 16 years old have allowed us to identify three ...
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Chapter and Conference Paper
Bone Marrow Transplantation for Thalassemia: 156 Cases Transplanted in Pesaro
Bone marrow transplantation can be used to radically cure homozygous thalassemia (1,2,3,4). We present here the results of marrow transplantation in 156 consecutive patients with beta-thalas-semia aged between...
