19 Result(s)
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Cullen M. Taniguchi
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Article
Open AccessUCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitochondria without off target effects in normal tissues that rely on these organelles is a ...
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Radiation Therapy for Pancreatic Cancer: Current and Evolving Paradigms
Pancreatic cancer is commonly treated with radiation therapy. While treatment paradigms vary by disease stage and are continuing to evolve, radiation therapy may play a role in the treatment of pancreatic canc...
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Open AccessFeasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model
Both modified FOLFIRINOX (mFFX) and gemcitabine/nab-paclitaxel chemotherapy regimens have been shown to improve clinical outcomes in patients with pancreatic cancer, and are often used interchangeably as the stan...
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Management of Locally Advanced/Metastatic Disease: Radiation Oncology
Patients with locally advanced pancreatic cancer (LAPC) have a dismal prognosis. Such tumors are unresectable, and optimal treatment with chemotherapy and/or radiation therapy is still not established. Radiati...
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Management of Resectable and Borderline Resectable Disease: Radiation Oncology
Surgical resection is the mainstay of curative treatment for pancreatic cancer. However, relapse rates with surgery alone are high. As systemic therapy improves, patients are living longer without metastatic d...
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APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis
Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal instability (CIN) remains unclear for many tumor types. Here, we identify CIN initiation as a previously undescribed func...
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Article
Open AccessFood and Drug Administration approvals in phase 3 Cancer clinical trials
Phase 3 oncologic randomized clinical trials (RCTs) can lead to Food and Drug Administration (FDA) approvals. In this study, we aim to identify trial-related factors associated with trials leading to subsequen...
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Open AccessAssessment of setup uncertainty in hypofractionated liver radiation therapy with a breath-hold technique using automatic image registration–based image guidance
Target localization in radiation therapy is affected by numerous sources of uncertainty. Despite measures to minimize the breathing motion, the treatment of hypofractionated liver radiation therapy is further ...
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Open AccessEnteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation
Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in ...
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Open AccessStem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro
Radiation therapy is one of the main treatment options for many cancer patients. Although high doses of radiation may maximize tumor cell killing, dose escalation is limited by toxicity to neighboring normal t...
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Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?
Hypoxia acts as an important regulator of physiological and pathological processes. Hypoxia inducible factors (HIFs) are the central players involved in the cellular adaptation to hypoxia and are regulated by ...
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Article
Open AccessIdentification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia
Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable st...
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A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
In two separate studies, Amato Giaccia and Calvin Kuo and colleagues show that targeting of hypoxia-inducible factor-2α to increase its expression results in elevation of a key downstream effector of insulin s...
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Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes
In two separate studies, Amato Giaccia and Calvin Kuo and colleagues show that targeting of hypoxia-inducible factor-2α to increase its expression results in elevation of a key downstream effector of insulin s...
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Chapter
Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis
The dominant hormone regulating metabolic homeostasis and the switch between the anabolic and catabolic states is insulin. At the cellular level, the action of insulin and the closely related insulin-like grow...
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Article
Erratum: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Nature 454, 1000–1004 (2008) In the Methods Summary of this Letter, the concentrations of IBMX and dexamethasone were incorrectly listed as 0.5 μM and 5 mM, respectively. The correct concentrations are 0.5 mM ...
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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Originally identified as a bone inducer, BMP-7 also has potent renal- and neuro-regenerative effects. Now it is reported to regulate energy homeostasis by promoting differentiation of brown, but not white, fat...
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Critical nodes in signalling pathways: insights into insulin action
The concept of 'critical nodes' has been used to define the main junctions in physiologically important, complex signalling networks. Several critical nodes of the insulin network have been identified and show...
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Article
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
The insulin/IGF-1 (insulin-like growth factor 1) signalling pathway promotes adipocyte differentiation via complex signalling networks. Here, using microarray analysis of brown preadipocytes that are derived f...
