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  1. No Access

    Article

    CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results

    Chimeric antigen receptor (CAR) T cells targeting CD22 (CD22-CAR) provide a therapeutic option for patients with CD22+ malignancies with progression after CD19-directed therapies. Using on-site, automated, closed...

    Liora M. Schultz, Nikeshan Jeyakumar, Anne Marijn Kramer, Bita Sahaf… in Leukemia (2024)

  2. Article

    Open Access

    Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma

    Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794),...

    Indu Ramachandran, Daniel E. Lowther… in Journal for ImmunoTherapy of Cancer (2019)

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  3. Article

    Open Access

    Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

    Chimeric Antigen Receptor (CAR) T cell therapies – adoptive T cell therapies that have been genetically engineered for a new antigen-specificity - have displayed significant success in treating patients with h...

    Michael M. Boyiadzis, Madhav V. Dhodapkar… in Journal for ImmunoTherapy of Cancer (2018)

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  4. No Access

    Article

    Neuroblastoma

    Neuroblastoma is the most common extracranial solid tumour occurring in childhood and has a diverse clinical presentation and course depending on the tumour biology. Unique features of these neuroendocrine tum...

    Katherine K. Matthay, John M. Maris… in Nature Reviews Disease Primers (2016)

  5. No Access

    Article

    Immune-based therapies for childhood cancer

  6. Graft-versus-leukaemic effects improve survival following allogeneic stem cell transplantation for childhood leukaemia, and provide proof-of-principle that imm...

    7. Crystal L. Mackall, Melinda S. Merchant, Terry J. Fry in Nature Reviews Clinical Oncology (2014)

  7. Article

    Open Access

    Enhanced glycolytic metabolism is associated with exhaustion and poor antitumor efficacy in a xenograft model of chimeric antigen receptor T cell therapy for sarcoma

    Adrienne H Long, Rimas J Orentas, Crystal L Mackall in Journal for ImmunoTherapy of Cancer (2013)

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  8. Article

    Open Access

    ALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors

    Rimas J Orentas, Paola Lopomo, William Babbitt… in Journal for ImmunoTherapy of Cancer (2013)

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  9. Article

    Open Access

    Neutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors

    Steven L Highfill, Adrienne H Long, Rimas J Orentas… in Journal for ImmunoTherapy of Cancer (2013)

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  10. No Access

    Article

    Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches

    Dendritic cells (DCs) serve as central regulators of adaptive immunity by presenting antigens and providing necessary co-signals. Environmental information received by the DCs determines the co-signals deliver...

    Terry J. Fry, Jessica L. Shand, Matthew Milliron… in Cancer Immunology, Immunotherapy (2009)

  11. No Access

    Chapter

    Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation

    Karl S. Peggs, Aviva C. Krauss… in Hematopoietic Stem Cell Transplantation (2009)

  12. No Access

    Article

    Immune reconstitution prevents metastatic recurrence of murine osteosarcoma

    Primary tumors develo** in immunocompetent hosts escape immunosurveillance by acquiring immune evasive properties. This raises the prospect that metastases derived from such tumors will also evade immunity. ...

    Melinda S. Merchant, Fraia Melchionda, Manoj Sinha… in Cancer Immunology, Immunotherapy (2007)

  13. Article

    IMPAIRED IMMUNE RECONSTITUTION POST SEQUENTIAL HIGH-DOSE CHEMOTHERAPY AND PERIPHERAL BLOOD PROGENITOR CELL (PBPC) INFUSION. † 962

    Dagmar T Stein, Crystal L Mackall, Catherine V Bare, Margaret R Brown… in Pediatric Research (1996)

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  14. Article

    SKEWING OF THE T CELL REPERTOIRE TOWARD A TARGET ANTIGEN DURING A PERIOD OF T CELL IMMUNE RECONSTITUTION. • 935

    Crystal L Mackall, Ronald E Gress in Pediatric Research (1996)

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