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    Article

    Tau Protein as a New Regulator of Cellular Prion Protein Transcription

    Cellular prion protein (PrPC) is largely responsible for transmissible spongiform encephalopathies (TSEs) when it becomes the abnormally processed and protease resistant form PrPSC. Physiological functions of PrP

    Laia Lidón, Cristina Vergara, Isidro Ferrer, Félix Hernández… in Molecular Neurobiology (2020)

  2. Article

    Open Access

    iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology

    Gerstmann-Sträussler-Scheinker (GSS) syndrome is a fatal autosomal dominant neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis, extrapyramidal signs and dementia. In some GSS...

    Andreu Matamoros-Angles, Lucía Mayela Gayosso… in Molecular Neurobiology (2018)

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    Article

    Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells

    The biological functions of the cellular prion protein remain poorly understood. In fact, numerous studies have aimed to determine specific functions for the different protein domains. Studies of cellular prio...

    Silvia Vilches, Cristina Vergara, Oriol Nicolás, Ágata Mata… in Molecular Neurobiology (2016)