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Open AccessMitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome
Rett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal development following a normal postnatal growth, which results in the loss of acquir...
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Cactus Pear as Colorants and Coloring Foods: Application in Different Food Matrices
Food color is one of the most important attributes related to consumer acceptance. The growth in consumer trends for the preference of healthy food colorants, clean-label foods, and attractive appearance, amon...
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Tau Protein as a New Regulator of Cellular Prion Protein Transcription
Cellular prion protein (PrPC) is largely responsible for transmissible spongiform encephalopathies (TSEs) when it becomes the abnormally processed and protease resistant form PrPSC. Physiological functions of PrP
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Picalm reduction exacerbates tau pathology in a murine tauopathy model
Genome-wide association studies (GWAS) have identified PICALM as one of the most significant susceptibility loci for late-onset Alzheimer’s disease (AD) after APOE and BIN1. PICALM is a clathrin-adaptor protein a...
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Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo
Neuropathological analysis in Alzheimer’s disease (AD) and experimental evidence in transgenic models overexpressing frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) mutant tau sugge...
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Article
Open AccessiPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology
Gerstmann-Sträussler-Scheinker (GSS) syndrome is a fatal autosomal dominant neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis, extrapyramidal signs and dementia. In some GSS...
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Article
Effect of Spray-Dried Flavonoid Microparticles on Oxidative Stability of Methyl Linoleate as Lipid Model System
Microencapsulated quercetin (Q) and epicatechin (E) were prepared by spray-drying using inulin (IN) as encapsulating agent (Q–IN and E–IN) as well as with Capsul (C) as channelizing agent (Q–IN–C and E–IN–C). ...
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Article
Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells
The biological functions of the cellular prion protein remain poorly understood. In fact, numerous studies have aimed to determine specific functions for the different protein domains. Studies of cellular prio...
