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  1. No Access

    Article

    Polymorphism in exon 7 of the endothelial nitric oxide synthase gene is associated with low incidence of microvascular damage in type 1 diabetic neuropathy

    Microvascular complications associated with type 1 diabetes mellitus (T1DM) are caused in part by endothelial dysfunction. We aimed to determine the association between polymorphisms in endothelial nitric oxid...

    Constantina Heltianu, Simona-Adriana Manea… in Central European Journal of Biology (2009)

  2. No Access

    Article

    Correlation of low molecular weight advanced glycation end products and nitric oxide metabolites with chronic complications in type 1 diabetic patients

    Advanced glycation end products (AGEs) are involved in the occurrence of vascular complications in diabetes. The present study was undertaken to investigate the level of low-molecular weight products of AGEs (...

    Constantina Heltianu, Simona-Adriana Manea… in Central European Journal of Biology (2008)

  3. No Access

    Article

    Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

    The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan1 on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5...

    John A Todd, Neil M Walker, Jason D Cooper, Deborah J Smyth, Kate Downes… in Nature Genetics (2007)

  4. No Access

    Article

    A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

    In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. W...

    Deborah J Smyth, Jason D Cooper, Rebecca Bailey, Sarah Field… in Nature Genetics (2006)

  5. No Access

    Article

    Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

    Deborah J Smyth, Joanna M M Howson, Christopher E Lowe, Neil M Walker… in Nature Genetics (2005)

  6. No Access

    Article

    Parameters for reliable results in genetic association studies in common disease

    It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to d...

    Ingrid Dahlman, Iain A. Eaves, Roman Kosoy, V. Anne Morrison… in Nature Genetics (2002)