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  1. No Access

    Article

    Modified Low Density Lipoproteins Decrease the Activity and Expression of Lysosomal Acid Lipase in Human Endothelial and Smooth Muscle Cells

    Lysosomal acid lipase (LAL), the only lysosomal enzyme involved in the hydrolysis of LDL-cholesteryl esters, is a key regulator of cellular cholesterol and fatty acid homeostasis and its deficiency contributes...

    Constantina Heltianu, Alexandra Robciuc, Gabriela Botez… in Cell Biochemistry and Biophysics (2011)

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    Article

    Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells

    Emerging evidence demonstrates the involvement of endothelin-1 (ET-1) in the pathophysiology of cardiovascular disorders associated with diabetes mellitus. The molecular mechanisms accountable for the increase...

    Simona-Adriana Manea, Adrian Manea, Constantina Heltianu in Cell and Tissue Research (2010)

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    Article

    Polymorphism in exon 7 of the endothelial nitric oxide synthase gene is associated with low incidence of microvascular damage in type 1 diabetic neuropathy

    Microvascular complications associated with type 1 diabetes mellitus (T1DM) are caused in part by endothelial dysfunction. We aimed to determine the association between polymorphisms in endothelial nitric oxid...

    Constantina Heltianu, Simona-Adriana Manea… in Central European Journal of Biology (2009)

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    Article

    Correlation of low molecular weight advanced glycation end products and nitric oxide metabolites with chronic complications in type 1 diabetic patients

    Advanced glycation end products (AGEs) are involved in the occurrence of vascular complications in diabetes. The present study was undertaken to investigate the level of low-molecular weight products of AGEs (...

    Constantina Heltianu, Simona-Adriana Manea… in Central European Journal of Biology (2008)

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    Article

    Protein and fatty acid composition of caveolae from apical plasmalemma of aortic endothelial cells

    In endothelial cells (EC), caveolae or plasmalemmal vesicles (PVs) represent a structurally and biochemically specialized membrane microdomain. Since few data are available on the biochemical composition of PV...

    Anca Gafencu, Mihaela Stanescu, Aurel Mircia Toderici… in Cell and Tissue Research (1998)

  6. No Access

    Article

    Identification of albumin-binding proteins of thymocyte plasmalemma

    In the present work we examined whether the interaction between albumin molecules and thymocytes involves albumin-binding proteins (ABP). Two plasmalemma-rich fractions obtained by differential centrifugation ...

    Ludy Dorbrila, Geo Serban, Constantina Heltianu in Bioscience Reports (1996)