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  1. Article

    Open Access

    The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia

    Dysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore, metabolic reprogramming constitutes a new hallmark of cancer. However, until today, only few therapeutic approaches exist...

    Estelle Erkner, Thomas Hentrich, Rebekka Schairer, Rahel Fitzel… in Oncogene (2024)

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  2. Article

    Open Access

    Inhibition of effector B cells by ibrutinib in systemic sclerosis

    Systemic sclerosis (SSc) is a connective tissue disease with a significant morbidity and reduced survival of patients. Effective treatment and clinical control of the disease remain challenging. In particular,...

    Jakob Einhaus, Ann-Christin Pecher, Elisa Asteriti… in Arthritis Research & Therapy (2020)

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    Article

    Inhibition of DOT1L and PRMT5 promote synergistic anti-tumor activity in a human MLL leukemia model induced by CRISPR/Cas9

    MLL rearrangements play a crucial role in leukemogenesis and comprise a poor prognosis. Therefore, new treatment strategies are urgently needed. We used the CRISPR/Cas9 system to generate an innovative leukemia m...

    Kathy-Ann Secker, Hildegard Keppeler, Silke Duerr-Stoerzer, Hannes Schmid… in Oncogene (2019)

  4. Article

    Open Access

    Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis

    Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lympho...

    Ann-Christin Pecher, Felix Kettemann, Elisa Asteriti… in Arthritis Research & Therapy (2019)

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  5. No Access

    Article

    Second allogeneic hematopoietic cell transplantation enables long-term disease-free survival in relapsed acute leukemia

    Allogeneic hematopoietic cell transplantation (HCT) is the treatment of choice for high-risk myeloid and lymphoid leukemias. Relapse after allogeneic HCT is associated with a dismal prognosis and further thera...

    Corina Schneidawind, Volker Hagmaier, Christoph Faul, Lothar Kanz… in Annals of Hematology (2018)