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Article
Open AccessClinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review
Patients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder cancer in advanced stages, and the degree of aggressiveness of malignancy is high. Most of the...
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Article
Open AccessResearch Advances in Stem Cell Therapy for Erectile Dysfunction
Erectile dysfunction (ED) is a common clinical condition that mainly affects men aged over 40 years. Various causes contribute to the progression of ED, including pelvic nerve injury, diabetes, metabolic syndr...
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Article
Open AccessIntegrative multi-omics analysis depicts the methylome and hydroxymethylome in recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression
Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictio...
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Article
Open AccessTumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven b...
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Article
Open AccessTargeting HNRNPU to overcome cisplatin resistance in bladder cancer
The overall response of cisplatin-based chemotherapy in bladder urothelial carcinoma (BUC) remains unsatisfactory due to the complex pathological subtypes, genomic difference, and drug resistance. The genes th...
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Article
Laparoscopic Adrenalectomy Versus Percutaneous Ablation for Aldosterone‑Producing Adenoma: a Meta-analysis
Aldosterone-producing adenoma (APA) is a relatively common form of benign adrenal tumor that can cause symptoms including hypertension, hypokalemia, and metabolic alkalosis. We aim to examine the safety and ef...
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Article
Open AccessIdentification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is one of the most lethal urological malignancies, but the pathogenesis and prognosis of ccRCC remain obscure, which need to be better understand.
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Article
Open AccessN6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation
Despite N6-methyladenosine (m6A) is functionally important in various biological processes, its role and the underlying regulatory mechanism in the liver remain largely unexplored. In the present study, we sho...
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Article
Open AccessA network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer
Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective m...
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Article
Open AccessA case of flank pain caused by ureteral intussusception accompanied with ureteral polyp
Ureteral intussusception, a rarely reported unique condition, occurs primarily as a complication of ureteric tumours.
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Article
A Mouse Model of Hypospadias Induced by Estradiol Benzoate
We wished to establish a mouse model of hypospadias using injections of estradiol benzoate for investigating the molecular mechanisms of hypospadias. Fifty timed pregnant mice were randomly divided into five s...
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Article
Optimization Studies on Prokaryotic Cell Expression of the Human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
The aim of the study was to optimize the in vitro induction and expression of the human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and also study the processes of its denaturation, renatur...
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Article
Protective Effects of Wusen Erlian Granules in Experimental Model of Viral Myocarditis
We wished to study the protective effects of Wusen Erlian granules, a therapy from traditional Chinese medicine, in experimental viral myocarditis (VMC). Sixty mice were divided into six groups: control group,...
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Article
In Vitro Cardioprotective Effect of Wusen Erlian Granules Through the Inhibition of Coxsackievirus B3 Replication
Wusen Erlian Granules are a traditional Chinese medicine and we sought to determine the antiviral activity of Wusen Erlian Granules against Coxsackievirus B3 infection. First, cytotoxicity of Wusen Erlian Gran...
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Article
Re-Transurethral Resection Treatment for Non-invasive Bladder Tumor
The objective of this study was to compare surgical treatments for non-invasive bladder tumor. Hundred and forty patients with non-invasive bladder tumor were studied. Seventy-three patients were treated by tr...
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Article
NRP-1 expression in bladder cancer and its implications for tumor progression
Neuropilin-1 (NRP-1) overexpression has been reported in a variety of human cancers. However, the role of NRP-1 in bladder cancer (BC) remains unclear. The aim of present study was to analyze NRP-1 protein exp...
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Article
The Transurethral Seminal Vesiculoscopy in the Diagnosis and Treatment of the Seminal Vesicle Disease
To develop a transurethral endoscopy technique of the transurethral seminal vesiculoscopy to examine and treat seminal vesicle disease. A total of 61 patients with seminal vesicle disease were diagnosed and tr...
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Article
Determination of thiol compounds by solid-phase extraction using multi-walled carbon nanotubes as adsorbent coupled with high-performance liquid chromatography-fluorescence detection
We describe a method for solid-phase extraction of biogenic thiols using multi-walled carbon nanotubes as adsorbent, and their subsequent determination via HPLC and fluorescence detection. The fluorogenic reag...
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Article
LC Determination of Thiols Derivatized with 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole after SPE
Solid-phase extraction (SPE) coupled with high-performance liquid chromatography–fluorescence detection (LC–FL) was developed for the determination of three thiol compounds including glutathione, cysteine and ...
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Article
Sensitive Determination of Thiols Using SPE Coupled to LC with Fluorescence Detection
Solid-phase extraction coupled with LC-fluorescence detection was used for the extraction and determination of three thiol compounds including glutathione (GSH), cysteine (Cys) and acetylcysteine (NAc). Fluore...
