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Open AccessWidespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2
Imprinted loci are paradigms of epigenetic regulation and are associated with a number of genetic disorders in human. A key characteristic of imprints is the presence of a gametic differentially methylated reg...
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Article
Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells
The IGF2 gene, which encodes a growth factor, is subject to genomic imprinting. The frequently observed loss of IGF2 imprinting in a variety of tumors has been suggested to contribute to neoplasia. Since these re...
