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  1. Article

    Open Access

    Impact of Myocardial Fibrosis on Cardiovascular Structure, Function and Functional Status in Heart Failure with Preserved Ejection Fraction

    Myocardial fibrosis, measured using cardiovascular magnetic resonance extracellular volume (ECV), is associated with adverse outcome in heart failure with preserved ejection fraction, but the mechanisms by whi...

    Gavin A. Lewis, Anna Rosala-Hallas… in Journal of Cardiovascular Translational Re… (2022)

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  2. Article

    Open Access

    Predictors of myocardial fibrosis and response to anti-fibrotic therapy in heart failure with preserved ejection fraction

    Myocardial fibrosis, measured using magnetic resonance extracellular volume (ECV), associates with adverse outcome in heart failure with preserved ejection fraction (HFpEF). In the PIROUETTE (The Pirfenidone i...

    Gavin A. Lewis, Anna Rosala-Hallas… in The International Journal of Cardiovascula… (2022)

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  3. No Access

    Article

    Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial

    In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent without hemodynamic effect, ...

    Gavin A. Lewis, Susanna Dodd, Dannii Clayton, Emma Bedson… in Nature Medicine (2021)

  4. Article

    Open Access

    Pirfenidone in Heart Failure with Preserved Ejection Fraction—Rationale and Design of the PIROUETTE Trial

    The PIROUETTE (PIRfenidOne in patients with heart failUre and preserved lEfT venTricular Ejection fraction) trial is designed to evaluate the efficacy and safety of the anti-fibrotic pirfenidone in patients wi...

    Gavin A. Lewis, Erik B. Schelbert, Josephine H. Naish… in Cardiovascular Drugs and Therapy (2019)

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  5. Article

    Open Access

    Non-invasive imaging of carotid arterial restenosis using 3T cardiovascular magnetic resonance

    Restenosis of the carotid artery is common following carotid endarterectomy, but analysis of lesion composition has mostly been based on histological study of explanted restenotic lesions. This study investiga...

    Alistair C Lindsay, Luca Biasiolli… in Journal of Cardiovascular Magnetic Resonan… (2014)

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  6. No Access

    Article

    Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models

    Mitochondrial aldehyde dehydrogenase-2 (ALDH-2) is involved in preconditioning pathways, but its role in remote ischaemic preconditioning (rIPC) is unknown. We investigated its role in animal and human models ...

    Hussain Contractor, Nicolaj B. Støttrup, Colin Cunnington… in Basic Research in Cardiology (2013)

  7. Article

    Open Access

    Association between aortic stiffness measured by cardiovascular magnetic resonance and sub-clinical carotid atherosclerosis in young adults

    Ilias Kylintireas, Colin Cunnington… in Journal of Cardiovascular Magnetic Resonan… (2009)

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  8. Article

    Open Access

    Cardiovascular magnetic resonance assessment of abdominal adiposity predicts early sub-clinical atherosclerosis in young adults: importance of relative adiposity

    Ilias Kylintireas, Jonathan Diesch… in Journal of Cardiovascular Magnetic Resonan… (2009)

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  9. Article

    Open Access

    Relationship of aortic stiffness measured by cardiovascular magnetic resonance to arterial stiffness estimates by tonometry

    Ilias Kylintireas, Colin Cunnington… in Journal of Cardiovascular Magnetic Resonan… (2009)

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