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Article
Adapting an Undergraduate Summer Internship to a Virtual Format: Implementing a Mentored Cancer Research Experience to Meet Rising Demand for Flexible Learning Environments
To meet the rising demand for flexible learning in data-driven health research, we adapted an in-person undergraduate research program (Quantitative Sciences Undergraduate Research Experience (QSURE)) to an al...
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Article
Open AccessMining mutation contexts across the cancer genome to map tumor site of origin
The vast preponderance of somatic mutations in a typical cancer are either extremely rare or have never been previously recorded in available databases that track somatic mutations. These constitute a hidden g...
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Article
Open AccessUsing somatic variant richness to mine signals from rare variants in the cancer genome
To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previous...
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Article
Open AccessAn EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients
We previously introduced a random-effects model to analyze a set of patients, each of which has two distinct tumors. The goal is to estimate the proportion of patients for which one of the tumors is a metastas...
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Article
Open AccessExamining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries
The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they shoul...
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Article
Proceedings of the third international molecular pathological epidemiology (MPE) meeting
Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformat...
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Article
Open AccessClonal relationships between lobular carcinoma in situ and other breast malignancies
Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extens...
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Article
Proceedings of the second international molecular pathological epidemiology (MPE) meeting
Disease classification system increasingly incorporates information on pathogenic mechanisms to predict clinical outcomes and response to therapy and intervention. Technological advancements to interrogate omi...
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Article
Open AccessGenomic investigation of etiologic heterogeneity: methodologic challenges
The etiologic heterogeneity of cancer has traditionally been investigated by comparing risk factor frequencies within candidate sub-types, defined for example by histology or by distinct tumor markers of inter...
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Article
Open AccessClonal relatedness between lobular carcinoma in situ and synchronous malignant lesions
Lobular carcinoma in situ (LCIS) has been accepted as a marker of risk for the development of invasive breast cancer, yet modern models of breast carcinogenesis include LCIS as a precursor of low-grade carcinomas...
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Article
Open AccessOne statistical test is sufficient for assessing new predictive markers
We have observed that the area under the receiver operating characteristic curve (AUC) is increasingly being used to evaluate whether a novel predictor should be incorporated in a multivariable model to predic...
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Article
MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study
We investigated whether MC1R genotype modifies the effect of sun exposure on melanoma risk in 1,018 cases with multiple melanomas (MPM) and 1,875 controls with one melanoma (SPM). There was some suggestion tha...
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Article
Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer
Given the greatly elevated risks of contralateral breast cancer (CBC) observed in breast cancer patients who carry mutations in BRCA1 and BRCA2, it is critical to determine the effectiveness of standard adjuvant ...
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Article
Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of develop...
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Article
Ambient UV, personal sun exposure and risk of multiple primary melanomas
Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one m...
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Article
HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case–control analyses
Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including...
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Article
Familial aggregation of melanoma risks in a large population-based sample of melanoma cases
ObjectiveMelanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases ...
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Article
Familial aggregation of melanoma risks in a large population-based sample of melanoma cases
ObjectiveMelanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases...
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Chapter and Conference Paper
Some Issues in the Comparison of Diagnostic Tests from a Paired Experiment
Data from a study to compare two diagnostic approaches for differentiating melanoma from atypical melanocytic nevi are analyzed. The study involved the paired-sample design, commonly used in diagnostic test ev...
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Article
Diverse prognosis in metastatic breast cancer: Who should be offered alternative initial therapies?
In an attempt to clarify appropriate treatment options for women with stage IV breast cancer, we studied the survival experience of a large dataset of patients treated on Cancer and Leukemia Group B (CALGB) pr...
