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Article
Open AccessFluorescence tracking demonstrates T cell recirculation is transiently impaired by radiation therapy to the tumor
T cells recirculate through tissues and lymphatic organs to scan for their cognate antigen. Radiation therapy provides site-specific cytotoxicity to kill cancer cells but also has the potential to eliminate th...
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Article
Open AccessA mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals
To develop a model of the internal vasculature of the adult liver and demonstrate its application to the differentiation of radiopharmaceutical decay sites within liver parenchyma from those within organ blood.
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Article
Modelling treatment-response rates
The time course of tumour responses to immunotherapies can be mathematically predicted on the basis of tumour-growth rates, the rates of immune activation and of tumour–immune-cell interactions, and the effica...
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Article
Assessing the interactions between radiotherapy and antitumour immunity
Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has transformed the treatment of cancer, enabling long-term tumour control even in individuals with advanced-stage disease. Unfortu...
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Article
Open AccessPretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy
Radiotherapy shows excellent local control in liver cancers but carries the risk of radiation-induced liver dysfunction and liver failure. We conducted a study of plasma hepatocyte growth factor (HGF) in a cli...
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Article
Open AccessAuthor Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessPrediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model
The goal of this work was to develop a mathematical model to predict Kaplan–Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial desig...
