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Article
Treat-to-Target in Atopic Dermatitis
Atopic dermatitis is one of the most common inflammatory skin diseases among children and adults. Over the last 5 years, the armamentarium for the treatment of this disease, with both topical and systemic drug...
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Article
Open AccessHigh-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome
Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes. It is one of the most prevalent chronic inflammatory skin conditions in adult...
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Article
Open AccessInterleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules
Psoriasis is an inflammatory disease characterized by leukocyte skin infiltration. Interestingly, recent works suggest that the migration of dendritic cells (DCs) is abnormal in psoriatic skin. DCs have signif...
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Article
Open AccessMeasuring serum concentrations of interleukin-33 in atopic dermatitis is associated with potential false positive results
In the search for valid biomarkers in inflammatory diseases, cytokine serum concentrations are often measured by enzyme-linked immunosorbent assay and correlated to disease activity. Interleukin-33 is a relati...
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Article
Open AccessAnti-inflammatory effect of a retrovirus-derived immunosuppressive peptide in mouse models
Short dimeric or mulitmeric peptides derived from a highly conserved stretch of amino acids from gammaretroviral envelope proteins has been found to have immunosuppressive properties in vitro. Here we test the hy...
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Article
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
Uncontrolled TLR signaling results in excessive inflammation. Arthur and colleagues show that the kinases MSK1 and MSK2 orchestrate a feedback loop involving interleukin 10 and the phosphatase DUSP1 to control...
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Article
1α,25(OH)2D3 regulates NF-κB DNA binding activity in cultured normal human keratinocytes through an increase in IκBα expression
NF-κB is a dimeric transcription factor which regulates transcription of a number of different genes including IL-8 and p53. In resting cells NF-κB is usually retained in an inactive state in the cytoplasm thr...
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Article
Growth medium-dependent ERK1/2 and AP-1 activity in cultured normal human keratinocytes modulates 1α,25-dihydroxyvitamin D3-induced differentiation
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Article
Modelling advective transport of Ulva lactuca (L) in the sheltered bay, Møllekrogen, Roskilde Fjord, Denmark
Biomass, grazing, sporulation, and growth of the free-floating macroalgae Ulva lactuca were measured in a small bay of 420 000 m2 inside Roskilde Fjord, Denmark. The measurements where made at 10 stations with a ...
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Article
Degradation of blood in the human digestive tract
Samples of human faeces from patients suffering from intestinal bleeding have been studied by use of Mössbauer spectroscopy. It is shown that it is possible to follow the degradation of blood in the digestive ...
