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Open AccessPhase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency
T-cell immunity is central for control of COVID-19, particularly in patients incapable of mounting antibody responses. CoVac-1 is a peptide-based T-cell activator composed of SARS-CoV-2 epitopes with documente...
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Open AccessBCR::ABL1 tyrosine kinase inhibitors hamper the therapeutic efficacy of blinatumomab in vitro
Acute B-lymphoblastic leukemia (B-ALL) is a malignant disease characterized by accumulation of clonal immature lymphocytes in the bone marrow and peripheral blood. The approval of BCR::ABL1 tyrosine kinase inh...
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Open AccessIdentification of CD105 (endoglin) as novel risk marker in CLL
Several genetic and clinical markers are established as prognostic factors in chronic lymphocytic leukemia (CLL). However, additional markers are needed for risk stratification. Flow cytometric analysis is a m...
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Open AccessA COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity
T cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based vaccine candidate, composed of SARS-CoV-2 T cell epitopes derived from various viral proteins1,2, combined with the Toll-...
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Open AccessCD105 (Endoglin) as negative prognostic factor in AML
While several genetic and morphological markers are established and serve to guide therapy of acute myeloid leukaemia (AML), there is still profound need to identify additional markers to better stratify patie...
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Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
Patients with acute myeloid leukaemia (AML) often achieve remission after therapy, but subsequently die of relapse1 that is driven by chemotherapy-resistant leukaemic stem cells (LSCs)2,3. LSCs are defined by the...
