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  1. Article

    Open Access

    Whole transcriptome profiling of Late-Onset Alzheimer’s Disease patients provides insights into the molecular changes involved in the disease

    Alzheimer’s Disease (AD) is the most common cause of dementia affecting the elderly population worldwide. We have performed a comprehensive transcriptome profiling of Late-Onset AD (LOAD) patients using second...

    Anita Annese, Caterina Manzari, Claudia Lionetti, Ernesto Picardi… in Scientific Reports (2018)

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  2. No Access

    Protocol

    Expression and Purification of Large Active GST Fusion Enzymes

    GST fusion proteins expressed in bacteria often tend to form aggregates and are inefficiently purified by standard procedures, which employ a mixture of detergents that compromise the binding efficiency to the...

    Stefania Deceglie, Claudia Lionetti, Marina Roberti… in Protein Downstream Processing (2014)

  3. No Access

    Chapter and Conference Paper

    Aplysia limacina Myoglobin: Molecular Bases for Ligand Binding

    The application of protein engineering techniques to hemoproteins has allowed the exploration of the role of distal residues and their ligand-binding functions in 02-carrying proteins (1). In the field of globins...

    Martino Bolognesi, Francesco Frigerio… in Structure and Function of Invertebrate Oxy… (1991)