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  1. No Access

    Article

    Multiphysics Simulation of Local Transport and Absorption Coupled with Pharmacokinetic Modeling of Systemic Exposure of Subcutaneously Injected Drug Solution

    Subcutaneous (SC) injectables have become more acceptable and feasible for administration of biologics and small molecules. However, efficient development of these products is limited to costly and time-consum...

    Clairissa D. Corpstein, Peng Hou, Kinam Park, Tonglei Li in Pharmaceutical Research (2023)

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    Article

    A Perspective on Model-Informed IVIVC for Development of Subcutaneous Injectables

    Subcutaneously administered drugs are growing in popularity for both large and small molecule drugs. However, development of these systems – particularly generics – is slowed due to a lack of formal guidance r...

    Clairissa D. Corpstein, Tonglei Li in Pharmaceutical Research (2023)

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    Article

    Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Sensitivity Analysis

    A multiphysics simulation model was recently developed to capture major physical and mechanical processes of local drug transport and absorption kinetics of subcutaneously injected monoclonal antibody (mAb) so...

    Peng Hou, Fudan Zheng, Clairissa D. Corpstein, Lei **ng… in Pharmaceutical Research (2021)

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    Article

    Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Model Development

    Many monoclonal antibodies (mAbs) are administered via subcutaneous (SC) injection. Local transport and absorption kinetics and mechanisms, however, remain poorly understood. A multiphysics computational model...

    Fudan Zheng, Peng Hou, Clairissa D. Corpstein, Lei **ng… in Pharmaceutical Research (2021)