Rubidomycin
A New Agent against Cancer
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Chapter and Conference Paper
Ten years of breast preserving management in infiltrative breast cancer : results in 412 patients treated by Neo-Adjuvant chemotherapy and radiation therapy with or without hormonotherapy
The studies that Claude Jacquillat undertook in 1980 in infiltrative breast cancers were inspired by two concepts: breast cancer should be considered in most women as a two components disease, a visible locore...
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Chapter and Conference Paper
Results of Cisplatin (CDDP)/Etoposide (VP16)/5-FU and alternatively Adriamycin or Mitomycin C (PEFAM) combination in primary resistant breast cancer and in heavily pre-treated metastatic breast cancer
In spite of the activity of chemotherapeutic agents, metastatic breast cancer remains an incurable disease.
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Chapter and Conference Paper
Difficultes dans l’Etablissement d’une Classification Pronostique a des Fins de Decision Therapeutique dans la Leucemie Aigue Lymphoblastique de l’Enfant
In acute lymphoblastic leukemia, the present therapeutic progress is due to a better use of the known chemotherapy: drugs association, different ways of administration, adaptation to severity… The therapeutic ...
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Article
A survey of the anthracycline derivatives in hematology
The anthracyclines, of which daunorubin (DNR), rubidazone (RBD), and adriamycin (ADR) are the most commonly used in cancer chemotherapy, belong to the group of intercalating agents capable of inhibiting the re...
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Chapter
A New Agent Active in the Treatment of Acute Myeloblastic Leukemia 22 050 RP
This report concerns our preliminary clinical experience in 44 cases of acute myeloblastic leukemia with 22 050 RP (Fig. 1), the benzoyl-hydrazone chlorhydrate of daunorubicin (DNR). Among the semi-synthetic d...
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Chapter
Recent Results in Acute Leukemias at the Hospital Saint-Louis
In this presentation, we shall briefly comment on some illustrations of our recent results in acute leukemias.
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Chapter
Treatment of Acute Leukemia with L-Asparaginase — Preliminary Results on 84 Cases
Between 1st of August 1968 and the 30th of April 1969 we treated 84 patients with L-asparaginase. This report deals with the results obtained.
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Book
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Chapter
Treatment of Acute Lymphoblastic Leukemia with Rubidomycin Only
Acute leukemias were first treated with rubidomycin alone, which enabled the effects of the new drug to be assessed as accurately as possible. Then they were treated with combinations of drugs, rubidomycin bei...
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Chapter
History of Rubidomycin
Although short, the history of rubidomycin can be divided into three periods.
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Chapter
Treatment of Chronic Leukemia, Sarcoma, Hodgkin’s Disease, and Cancer with Rubidomycin
Chronic myelocytic period. Many therapeutic agents, among which Busulfan and radiotherapy occupy the first rank but which also include 6-mercaptopurine, dibromomannitol, and hydroxyurea, can bring about good remi...
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Chapter
Structure
Daunomycin hydrochloride1 (m.p. 188–190° decomp, [α]d = +253° (methanol)) has an absorption spectrum in the ultraviolet and visible regions very similar to those of the 1,4,5-trihydroxyanthraquinones. It shows, i...
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Chapter
Fixation in the Cell and Mechanism of Action
Except for recent papers by di Marco et al., one of which [67] deals with the in vitro investigation of its metabolization by tissue extracts, the other [65] with blood and urine determinations in the animals tre...
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Chapter
Posology
Rubidomycin can be used alone or in association with other drugs. The dose varies according to the disease and according to the stage of the disease, the details being given elsewhere for each of the main ther...
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Chapter
Introduction
Trials in the treatment of the leukemias are sometimes based on a hypothesis, as in the case of exchange transfusion [33] or the use of antimetabolites [86]. Or they are conducted empirically as the results of...
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Chapter
Cytological and Immunological Study of Acute Leukemia Treated with Rubidomycin
The various therapeutic methods applied to acute leukemia undoubtedly alter the leukemic cells as well as the normal cells. Marrow megaloblastosis was seen, as had been anticipated, as soon as antifolic agents...
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Chapter
Preparation
Rubidomycin1, obtained from cultures of Streptomyces coeruleorubidus [63, 79, 80, 184], is a basic antibiotic, orange-red in color, belonging to the group studied by Ollis and Sutherland [175]. This group of anti...
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Chapter
Conclusions
Rubidomycin, an antibiotic with antitumoral activity, is extracted from several strains of Streptomyces coeruleorubides.
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Chapter
Toxicology
The acute toxicity of rubidomycin was determined in several animal species (mouse, rat, guinea-pig, rabbit, and dog) and its subacute toxicity in the mouse.
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Chapter
Combination Therapy in the Treatment of Acute Leukemia
The use of sequential or combination therapy in the treatment of acute leukemia was proposed by one of us in 1952 in the case of aminopterine and cortisone [28]. The value of such treatment was questioned for ...
